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To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Basic/Clinical Science Session

Hypertension Is an Immune-Mediated Disease

November 04, 2022 | 10:30 AM - 12:30 PM

Location: W311, Orange County Convention Center‚ West Building

Session Description

Hypertension is a major contributor to target organ damage with excess morbidity and mortality. This session examines the role of the immune system in the pathogenesis of hypertension. Particular emphasis is given to the role monocyte activation plays in the setting of excess dietary salt-induced BP elevation. Inhibition of monocytes is explored as a novel approach to the treatment of hypertension. This session also covers the role of an octameric protein complex involved in Bardet-Biedl syndrome (BBSome) in the pathogenesis of hypertension.

Learning Objective(s)

  • Define the role of the immune system in contributing to the development of systemic hypertension
  • Discuss the role of monocytes as novel therapeutic targets in the treatment of hypertension
  • Describe the effects of minocycline as a treatment for resistant hypertension

Learning Pathway(s)

  • Hypertension and Cardiorenal Disorders


  • Susan B. Gurley, MD, PhD
  • Jennifer L. Pluznick, PhD


  • Is Hypertension an Immune Disease?
    10:30 AM - 11:00 AM
    David G. Harrison, MD
  • Monocytes as Immune Targets in Arterial Hypertension
    11:00 AM - 11:30 AM
    Philip Wenzel, MD
  • Minocycline as a Treatment of Resistant Hypertension: Results of a Clinical Study
    11:30 AM - 12:00 PM
    Eileen M. Handberg, PhD, APRN, RN
  • Role of Immune Cells in Hypertension
    12:00 PM - 12:30 PM
    Ernesto L. Schiffrin, MD, PhD