ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Translational Session

Molecular Mechanisms of Hypertension and Cardiovascular Effects

November 06, 2022 | 09:30 AM - 11:30 AM

Location: W308, Orange County Convention Center‚ West Building

Session Description

This session provides information on some of the latest breakthroughs in our understanding of the roles of bile acids, angiogenic factors, gut microbiome derived factors, and circadian rhythm in the regulation of BP. In addition, presenters discuss some of the pathogenic links between elevated BP and CKD as revealed using human and animal genomic studies.

Learning Objective(s)

  • Examine the effect of the nonangiogenic, maternally sequestered protein ELP-VEGF B as a potential therapeutic for preeclampsia
  • Discuss adverse cardiorenal outcomes and increased risk of cardiovascular mortality associated with dysregulation of the circadian rhythm of BP
  • Understand the role of the gut microbiome and microbiome derived metabolites in systemic inflammation and cardiovascular complications of CKD
  • Describe the association of impaired bile acid signaling with dietary salt-induced elevations in BP

Learning Pathway(s)

  • Hypertension and Cardiorenal Disorders


  • Bryan Becker, PhD
  • Mahboob Rahman, MBBS, MD