Basic/Clinical Science Session
Nephron Endowment and Links to Cessation of Nephrogenesis
November 04, 2022 | 10:30 AM - 12:30 PM
Location: W240, Orange County Convention Center, West Building
Session Description
Nephron formation reaches completion near the end of gestation, after which no new nephrons are formed. The final nephron complement can vary 10-fold, with reduced nephron number predisposing individuals to hypertension, kidney, and cardiovascular diseases in later life. This session delves into the critical issue of why nephrogenesis ends. Presenters discuss mechanisms by which nephrogenesis is maintained and terminated.
Learning Objective(s)
- Define the role of signaling from GDNF, Wnt, and Tsc1 in the cessation of nephrogenesis
- Discuss human and model organism studies about the determinants of nephron number
- Outline the regulators of developmental time in mammalian nephron formation
Learning Pathway(s)
- Pediatric Nephrology
- Genetic Diseases and Development
Moderator
- Jennifer R. Charlton, MD, MS
Presentations
- Progenitor Translatome Changes End Nephrogenesis
10:30 AM - 11:00 AM
Raphael Kopan, PhD
- Prolongation of Mammalian Nephrogenesis by Excess Fetal Glial Cell Line-Derived Neurotrophic Factor
11:00 AM - 11:30 AM
Satu Kuure, PhD
- Lin28 and Let-7 Regulate Cessation of Murine Nephrogenesis
11:30 AM - 12:00 PM
Jihan Osborne, PhD
- Chromatin Changes in Nephron Progenitors
12:00 PM - 12:30 PM
Samir S. El-Dahr, MD
