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To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Basic/Clinical Science Session

Nephron Endowment and Links to Cessation of Nephrogenesis

November 04, 2022 | 10:30 AM - 12:30 PM

Location: W240, Orange County Convention Center‚ West Building

Session Description

Nephron formation reaches completion near the end of gestation, after which no new nephrons are formed. The final nephron complement can vary 10-fold, with reduced nephron number predisposing individuals to hypertension, kidney, and cardiovascular diseases in later life. This session delves into the critical issue of why nephrogenesis ends. Presenters discuss mechanisms by which nephrogenesis is maintained and terminated.

Learning Objective(s)

  • Define the role of signaling from GDNF, Wnt, and Tsc1 in the cessation of nephrogenesis
  • Discuss human and model organism studies about the determinants of nephron number
  • Outline the regulators of developmental time in mammalian nephron formation

Learning Pathway(s)

  • Pediatric Nephrology
  • Genetic Diseases and Development


  • Jennifer R. Charlton, MD, MS
  • Greg R. Dressler, PhD