ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Basic/Clinical Science Session

Nephron Progenitor Fate Determination and Maintenance

November 06, 2022 | 09:30 AM - 11:30 AM

Location: W315, Orange County Convention Center, West Building

Session Description

Low nephron endowment at birth may lead to hypertension and cystic kidney disease in adult life. This session addresses the critical mechanisms that underlie the control of nephron progenitor number. Transcriptional control and epigenetic and cell biological mechanisms of regulating progenitor number are discussed.

Learning Objective(s)

  • Define the role of transcription factors and signaling in nephrons
  • Describe the epigenetic regulation of nephrogenesis
  • Outline the roles of cell migration in progenitor commitment

Learning Pathway(s)

  • Genetic Diseases and Development


  • Cristina Cebrian Ligero, PhD
  • Lori L. O'Brien, PhD


  • Transcriptional Regulation of Nephron Progenitors
    09:30 AM - 10:00 AM
    Nils Lindstrom, PhD
  • Nephron Progenitor Commitment Is a Stochastic Process Influenced by Cell Migration
    10:00 AM - 10:30 AM
    Alexander N. Combes, PhD
  • Chromatin Interactions with Transcription Factors in Progenitor Maintenance
    10:30 AM - 11:00 AM
    Pin-Xian Xu Xu, MS, MSc, PhD
  • Chromatin Accessibility in Progenitors
    11:00 AM - 11:30 AM
    Dennis Kostka, PhD