Basic/Clinical Science Session
Role of Basolateral Potassium Channel in Potassium Homeostasis and Diseases
November 05, 2022 | 10:30 AM - 12:30 PM
Location: W230, Orange County Convention Center, West Building
Session Description
Basolateral potassium channels in nephrons have an important role in kidney potassium and sodium handling. Mutations in these potassium channels result in significant electrolyte disorders and affect hemodynamic state. This session discusses the roles of kidney basolateral potassium channels in salt wasting disorder and kidney sodium handling. Presentations explore the mechanisms underlying the roles of these potassium channels as well as potential therapeutic agents that target them.
Learning Objective(s)
- Define potassium homeostasis
- Describe the electrolyte disorders caused by mutations in these potassium channels
- Discuss the mechanisms underlying the roles of basolateral potassium channels in electrolyte disorder and kidney and cardiovascular diseases
- Explore the potential utility of potassium channel inhibitors
Learning Pathway(s)
- Fluid, Electrolyte, and Acid-Base Disorders
- Kidney Biology and Physiology
Moderators
- Chou-Long Huang, MD, PhD
- Janet D. Klein, PhD
Presentations
- Physiological and Pathophysiological Roles of Kir5.1 (KCNJ16) in the Kidneys
10:30 AM - 11:00 AM
Alexander Staruschenko, PhD, FASN
- Kir4.1/Kir5.1 in the Distal Convoluted Tubule Regulates Potassium Homeostasis
11:00 AM - 11:30 AM
WenHui Wang, MD
- WNKs are Potassium-Sensitive Kinases
11:30 AM - 12:00 PM
Aylin R. Rodan, MD, PhD, FASN
- Next-Generation Inward Rectifier Potassium Channel Modulators: Discovery and Molecular Pharmacology
12:00 PM - 12:30 PM
Jerod S. Denton, MS, PhD
