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To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Educational Symposium

Complement in IgA Nephropathy and Lupus Nephritis: Role in Pathogenesis and Implications for Treatment

November 04, 2022 | 12:45 PM - 01:45 PM

Location: Windermere Ballroom X, Hyatt Regency Orlando

Session Description

This symposium focuses on the role of complement in the pathogenesis of IgA nephropathy and lupus nephritis. For IgA nephropathy, the focus is the contributions of the alternative and lectin binding pathways to glomerular pathobiology. Discussion includes activation markers and their association with disease prognosis, and updates are provided on the early results of clinical trials evaluating drugs that inhibit these pathways as potential therapies for IgA nephropathy. The presentation about lupus nephritis elucidates the role of complement activation in mediating glomerular inflammation in response to immune complex deposition. Also reviewed are the pathogenesis of lupus-associated thrombotic microangiopathies and data from animal models and human studies. This understanding of disease pathogenesis underlies the discussion of the potential of complement inhibition as a therapeutic approach to kidney diseases in lupus.

Support is provided by an educational grant from Alexion Pharmaceuticals, Inc.

Learning Objective(s)

  • Discuss the importance of complement activation in the pathogenesis of IgA nephropathy, the association of complement deposition with clinical prognosis, and the current status of complement-based therapeutic approaches to IgA nephropathy
  • Describe the roles of complement in the pathogenesis of lupus nephritis and thrombotic microangiopathy in patients with systemic lupus erythematosus and the potential roles of complement inhibitors in treating them

Learning Pathway(s)

  • Glomerular Diseases
  • Kidney Biology and Physiology