Educational Symposium
Complement in IgA Nephropathy and Lupus Nephritis: Role in Pathogenesis and Implications for Treatment
November 04, 2022 | 12:45 PM - 01:45 PM
Location: Windermere Ballroom X, Hyatt Regency Orlando
Session Description
This symposium focuses on the role of complement in the pathogenesis of IgA nephropathy and lupus nephritis. For IgA nephropathy, the focus is the contributions of the alternative and lectin binding pathways to glomerular pathobiology. Discussion includes activation markers and their association with disease prognosis, and updates are provided on the early results of clinical trials evaluating drugs that inhibit these pathways as potential therapies for IgA nephropathy. The presentation about lupus nephritis elucidates the role of complement activation in mediating glomerular inflammation in response to immune complex deposition. Also reviewed are the pathogenesis of lupus-associated thrombotic microangiopathies and data from animal models and human studies. This understanding of disease pathogenesis underlies the discussion of the potential of complement inhibition as a therapeutic approach to kidney diseases in lupus.
Support is provided by an educational grant from Alexion Pharmaceuticals, Inc.
Learning Objective(s)
- Discuss the importance of complement activation in the pathogenesis of IgA nephropathy, the association of complement deposition with clinical prognosis, and the current status of complement-based therapeutic approaches to IgA nephropathy
- Describe the roles of complement in the pathogenesis of lupus nephritis and thrombotic microangiopathy in patients with systemic lupus erythematosus and the potential roles of complement inhibitors in treating them
Learning Pathway(s)
- Glomerular Diseases
- Kidney Biology and Physiology
Moderator
Presentations
- Introduction
12:45 PM - 12:55 PM
- Complement in IgA Nephropathy: Pathogenic Role and Potential Therapeutic Target
12:55 PM - 01:15 PM
- Glomerulonephritis and Thrombotic Microangiopathy in Lupus Nephritis: Role of Complement in Pathogenesis and Therapeutic Implications
01:15 PM - 01:35 PM
- Questions and Answers
01:35 PM - 01:45 PM