Kidney Week

Basic/Clinical Science Session

Pragmatic Clinical Trials as Means to Update Clinical Practice in CKD-MBD

November 03, 2023 | 02:00 PM - 04:00 PM

Location: Room 119, Pennsylvania Convention Center

Session Description

Many unanswered questions about how best to treat patients on dialysis with hyperphosphatemia and secondary hyperparathyroidism remain. Advances in clinical trial methodology afford the opportunity to begin to answer questions in the management of CKD-MBD through pragmatic clinical trials embedded into clinical practice. This session reviews prior pragmatic trials and lessons learned, provides overviews of two ongoing pragmatic clinical trials focused on the management of hyperphosphatemia, and discusses steps to design a pragmatic clinical trial for secondary hyperparathyroidism.

Learning Objective(s)

• Summarize prior pragmatic trials and lessons learned that could be applied to the area of CKD-MBD
• Provide an overview of the HiLo Trial
• Provide an overview of the PHOSPHATE Trial
• Build the case for a pragmatic clinical trial for the management for secondary hyperparathyroidism

Learning Pathway(s)

• Bones‚ Stones‚ and Mineral Metabolism
• Dialysis

Moderators

• Orlando M. Gutierrez, MD
• Michal L. Melamed, MD

Presentations

• Overview of Prior Pragmatic Clinical Trials in Dialysis and Applications to CKD-MBD
  02:00 PM - 02:30 PM
  
  • Andrea Cowan, MD
  Andrea Cowan, MD

Overview of Prior Pragmatic Clinical Trials in Dialysis and Applications to CKD-MBD

November 03, 2023 | 02:00 PM - 02:30 PM

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• Overview of the HiLo Trial
  02:30 PM - 03:00 PM
  
  • Daniel Edmonston, MD
  Daniel Edmonston, MD

Overview of the HiLo Trial

November 03, 2023 | 02:30 PM - 03:00 PM

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• Overview of the PHOSPHATE Trial
  03:00 PM - 03:30 PM
  
  • Ron Wald, MD, MPH
  Ron Wald, MD, MPH

Overview of the PHOSPHATE Trial

November 03, 2023 | 03:00 PM - 03:30 PM

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• Rationale for a Pragmatic Clinical Trial for Management of Secondary Hyperparathyroidism
  03:30 PM - 04:00 PM
  
  • Julia J. Scialla, MD, FASN
  Julia J. Scialla, MD, FASN

Rationale for a Pragmatic Clinical Trial for Management of Secondary Hyperparathyroidism

November 03, 2023 | 03:30 PM - 04:00 PM

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