Kidney Week

Oral Abstract Session

Monogenic Kidney Disease: Mechanistic Insights and Therapeutic Approaches

November 07, 2025 | 04:30 PM - 06:00 PM

Location: Room 360A, Convention Center

Session Description

Oral Abstract Session

Note: Continuing education credits are not being offered for this session.

Learning Pathway(s)

• Genetic Diseases and Development

Moderators

• Andreia Watanabe, MD, PhD
• Terry J. Watnick, MD

Presentations

• Alternative Splicing Dysregulation by Pin1 Mediates Tuberous Sclerosis Kidney Disease
  04:30 PM - 04:40 PM
  
  • Morris Nechama, PhD

Alternative Splicing Dysregulation by Pin1 Mediates Tuberous Sclerosis Kidney Disease

November 07, 2025 | 04:30 PM - 04:40 PM

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• Allele-Selective Antisense Oligonucleotide Targeting Uromodulin Reduces Toxic Aggregates and Rescues Kidney Damage in Models of UMOD-Related Autosomal Dominant Tubulointerstitial Kidney Disease
  04:40 PM - 04:50 PM
  
  • Olivier Devuyst, MD, PhD

Allele-Selective Antisense Oligonucleotide Targeting Uromodulin Reduces Toxic Aggregates and Rescues Kidney Damage in Models of UMOD-Related Autosomal Dominant Tubulointerstitial Kidney Disease

November 07, 2025 | 04:40 PM - 04:50 PM

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• Mesencephalic Astrocyte-Derived Neurotrophic Factor Orchestrates Endoplasmic Reticulum (ER)-Mitochondrial Calcium Homeostasis in Genetic CKD
  04:50 PM - 05:00 PM
  
  • Yili Fang, MD, PhD

Mesencephalic Astrocyte-Derived Neurotrophic Factor Orchestrates Endoplasmic Reticulum (ER)-Mitochondrial Calcium Homeostasis in Genetic CKD

November 07, 2025 | 04:50 PM - 05:00 PM

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• Targeting Metabolic Dysfunction in Cystinosis Proximal Tubular Epithelial Cells
  05:00 PM - 05:10 PM
  
  • Sante Princiero Berlingerio, PhD

Targeting Metabolic Dysfunction in Cystinosis Proximal Tubular Epithelial Cells

November 07, 2025 | 05:00 PM - 05:10 PM

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• Deciphering the Effect of RAC1-SPTAN1 in Autosomal Recessive PKD (ARPKD) Cystogenesis Using Multifaceted Models
  05:10 PM - 05:20 PM
  
  • Shohei Kuraoka, MD, PhD

Deciphering the Effect of RAC1-SPTAN1 in Autosomal Recessive PKD (ARPKD) Cystogenesis Using Multifaceted Models

November 07, 2025 | 05:10 PM - 05:20 PM

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• Endoplasmic Reticulum-Mitochondrion Disconnection Promotes Epigenetic Rewiring and Cystogenesis in PKD
  05:20 PM - 05:30 PM
  
  • Biswajit Padhy, PhD

Endoplasmic Reticulum-Mitochondrion Disconnection Promotes Epigenetic Rewiring and Cystogenesis in PKD

November 07, 2025 | 05:20 PM - 05:30 PM

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• Precise Editing of the Central Six Nucleotides in the Pkd1-3’UTR miR-17 Binding Motif Is Sufficient to Restore Pkd1 and Slow PKD Progression
  05:30 PM - 05:40 PM
  
  • Chunzi Song, MD

Precise Editing of the Central Six Nucleotides in the Pkd1-3’UTR miR-17 Binding Motif Is Sufficient to Restore Pkd1 and Slow PKD Progression

November 07, 2025 | 05:30 PM - 05:40 PM

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• Protective Effect of a Human Pregnancy-Associated Plasma Protein A IgG Monoclonal Antibody in an Orthologous ADPKD Mouse Model
  05:40 PM - 05:50 PM
  
  • Xiaofang Wang

Protective Effect of a Human Pregnancy-Associated Plasma Protein A IgG Monoclonal Antibody in an Orthologous ADPKD Mouse Model

November 07, 2025 | 05:40 PM - 05:50 PM

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• Antisense Oligonucleotide-Mediated Polycystin 1 Upregulation by Enhancing PKD1 Translation Has the Potential to Treat ADPKD
  05:50 PM - 06:00 PM
  
  • Xuehai Liang, PhD

Antisense Oligonucleotide-Mediated Polycystin 1 Upregulation by Enhancing PKD1 Translation Has the Potential to Treat ADPKD

November 07, 2025 | 05:50 PM - 06:00 PM

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