RE: Parathyroid mass with severe hypercalcemia 59 minutes ago

Hello to all, So here's the update for our patient. He underwent left parathyroid resection 3 days ago; the left superior parathyroid gland wa...

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True hyponatremia and normal osmolality 3 hours ago

An 81 yr old female was admitted with a COPD exacerbation, respiratory acidosis 3 days ago. She was found to be hyponatremic with a Serum Na of 126...

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probable/ possible ABMR dilemma 4 hours ago

Hi All, after the Banff 2022 update, a new entity of probable and possible ABMR has been introduced. also the category of MVI with negative C4d ...

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RE: Kidney transplantation in a child with C3G/DDD 4 hours ago

thank you in case of recurrence, what therapy do you prefer to use ? @Mark Lerman ------------------------------ Ahmed Emara MD, FASN Ain sha...

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RE: AKI/CLL/Nephritic syndrome 7 hours ago

Dr. Venkat I understand the points you made. I agree that if a glomerular disorder is present, it is most likely MGRS and that the therapy is clon...

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RE: Recurrence of C3 Glomerulopathy After Kidney Transplantation ? 10 hours ago

Or even Iptacopan would be a better option over Ravulizumab/ Eculizumab.. it all depends in the cost, availability, insurance .. though for us Pegc...

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RE: A case of AKI 14 hours ago

The Pemetrexed is very liklrky involved in the AKI-CKD transition in this case. , This agent is well l known to cause a late CKD progression (*irre...

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RE: A case of AKI 15 hours ago

Appreciate everyone’s input She’s on atorvastatin 40mg , cpk and lfts within normal range, renal us showed no hydonephrosis , size about 10cm b/l ...

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RE: A case of AKI 16 hours ago

This is very likely AKI (nephrotoxic) transitioning to CKD. Did the patient receive magnesium and Saline infusions with the Cisplatinum. Any chance...

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RE: A case of AKI 16 hours ago

"only taking statin" Is she on rosuvastatin? I bring this up given the association between this statin and elevation of SCr. Also, results of kid...

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RE: Non Lupus Full house nephropathy management 17 hours ago

Given problems with insurance approval for rituximab and a membranous-pattern of injury, isn't a combination of mycophenolate + CNI + prednisone ap...

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RE: A case of AKI 17 hours ago

2 of 24 glomeruli are sclerotic yet there is severe IFTA 30% this is Cis-p almost certainly and I have seen the CKD continue to progress month...

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RE: Non Lupus Full house nephropathy management 18 hours ago

@Lynn Cornell Thank you Lynn for sharing this jewel by Dr. Jennette el al. Forty years later, we have EXT1,2 as markers for autoimmune membranous...

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RE: Non Lupus Full house nephropathy management 18 hours ago

It sounds like this is a membranous glomerulonephritis pattern of injury, with some features (IF) suggestive of membranous lupus nephritis. There a...

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RE: A case of AKI 19 hours ago

Not aware of any TMA incident, the initial thought that this was Cisplatin induced AKI but would assume her Cr to improve as it’s been 5 months sin...

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RE: Membranous Nephropathy- Resistant Nephrotic Syndrome 19 hours ago

the biopsy was not stained for antiPLA2R His antiPLAr2 was 100 in Jan 25, 10 by June and [More]

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RE: A case of AKI 19 hours ago

Tough case. 30% IFTA with lack of glomerular pathology suggests Cisplatinum induced tubulointerstitial injury. The microvascular pathology is worri...

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RE: Non Lupus Full house nephropathy management 19 hours ago

This is behaving like a case of "Idiopathic" non-Lupus Full house MN. (NLFHMN) She may develop full blown Lupus on serial exams. The tendency fir l...

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A case of AKI 19 hours ago

Dear colleagues, appreciate your input for this case A 63 Y/o woman with PMHx of Lung cancer S/p Rt lobectomy in 3/2025 , completed 4 cycles o...

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RE: Non Lupus Full house nephropathy management 20 hours ago

This is a little tangential to your principal question, but let me point out that proteinuria in membranous lupus (if that's what she has) can take...

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RE: Membranous Nephropathy- Resistant Nephrotic Syndrome 21 hours ago

Was the biopsy stained for PLA2R antigen? what has been the course of his serum anti-PLA2R antibody levels, by ELISA? Have you measured an anti-PLA...

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RE: Membranous Nephropathy- Resistant Nephrotic Syndrome 21 hours ago

Dr. Dastoor at your lab what is the lower reference for anti PLA2R by ELISA? ------------------------------ Emilio Venturelli MD Scuola di speci...

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Membranous Nephropathy- Resistant Nephrotic Syndrome 22 hours ago

I saw a 34 year old gentleman today , who in October 2024 , was diagnosed with Biopsy proven Membranous Nephropathy and a Postive high titer of ant...

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RE: Non Lupus Full house nephropathy management 23 hours ago

Here is the full detail. I didn't see her as an outpatient. I saw her in the hospital this time. Patient is a 26-year-old female with medical hx ...

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RE: Recurrence of C3 Glomerulopathy After Kidney Transplantation ? 23 hours ago

I would prefer Pegcetacoplan over Eculizumab or Ravulizumab for prevention/ therapy of recurrent C3GN in a kidney allograft. --------------------...

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RE: Non Lupus Full house nephropathy management 23 hours ago

Sorry, I misread it ... It's Membranous not MPGN. --------------------------------- Dr. Hormaz Dastoor. MD, FASN Nephrology Consultant - Seha Kid...

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RE: Recurrence of C3 Glomerulopathy After Kidney Transplantation ? 23 hours ago

The rapid loss of renal function after kidney transplant and low C3 , C3 dominance on biopsy suggests a disease of the alternate pathway . There ...

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RE: Recurrence of C3 Glomerulopathy After Kidney Transplantation ? 23 hours ago

I only have antibody results from 2019 and 2021, and they were negative. In 2029, prior to transplantation: C3: decreased (consumed) C4: with...

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RE: white male with collapsing FSGS 1 day ago

Yes, Dr. Glassock, you are correct- this was a positiveEB-VCA IgM assay. he has not received any immunosuppressive therapy so infectious disease a...

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RE: white male with collapsing FSGS 1 day ago

This is a positive EB-VCA IgM assay- correct? Consistent with an acute EB viral infection, possibly causative for the Collapsing FSGS lesion- The c...

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RE: Non Lupus Full house nephropathy management 1 day ago

Please clarify- the LM and EM lesion in this patient is Membranous Nephropathy, not MPGN . The IF is "full house " and the serology is negative for...

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RE: Non Lupus Full house nephropathy management 1 day ago

The patient i described as "Young. " How likely is the patient to have monoclonal disorders including light chain nephropathy? -----------------...

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RE: white male with collapsing FSGS 1 day ago

I wanted to update everyone with an interesting development. This man ended up having positive/elevated Epstein-Barr virus IgM! I consulted infec...

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RE: Non Lupus Full house nephropathy management 1 day ago

If the LM is an MPGN lesion , then then full house pattern suggests IC- MPGN In this case you would need to rule out infections , immunological an...

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RE: Lupus - Steroid free management options 1 day ago

She never was intentionally non complaint , it was mainly financial .. since IV infusions were covered by insurance she continued taking IV Belimum...

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RE: Lupus - Steroid free management options 1 day ago

With a history of poor compliance to MMF ,do you plan to monitor blood levels of MPA during this therapy? ------------------------------ Richard ...

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RE: Non Lupus Full house nephropathy management 1 day ago

I generally concur with your statement. The "full house , non lupus MN" pattern of injury might be due to a chronic viral infection like HBV, but w...

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RE: Non Lupus Full house nephropathy management 1 day ago

It is important to investigate the underlying cause of the full-house pattern on biopsy. Exclusion of an infection is essential, as well as evaluat...

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RE: Lupus - Steroid free management options 1 day ago

Yes , we have OBI available now to us after the FDA approval. I was hoping to start her MMF and see how it influences her dsDNA titer in 3 months ...

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RE: Non Lupus Full house nephropathy management 1 day ago

Unfortunately, there are no RCT to inform us regarding optimum therapy for "full house non-lupus MN" -a descriptive term for a "pattern of injury" ...

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Non Lupus Full house nephropathy management 1 day ago

Hi all, I need opinion. I have a young patient who presented with proteinuria and worsening renal function now. She was seen about 8 months ago fir...

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RE: Parathyroid mass with severe hypercalcemia 1 day ago

Eagerly awaiting update on surgical findings and post-surgery outcomes in your patient. Blood sampling and intraoperative PTH measurements on the v...

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RE: Friday : Unexplained metabolic acidosis 1 day ago

What is under the hood? Changes in e-KF [estimated Kidney Function] may change the direction of the electrons and protons in this engine under...

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RE: Kidney transplantation in a child with C3G/DDD 1 day ago

Would only proceed with transplant after very careful discussion with the patient and the potential donor regarding the high likelihood of recurren...

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RE: Lupus - Steroid free management options 1 day ago

While Dr Rodby and I disagree on the definition of a remission in LN , we both agree that at a kidney biopsy is not needed and that additional anti...

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RE: Lupus - Steroid free management options 1 day ago

I always classify my lupus GN patents in clinical and serologic remission and there can be any combination of that. Complete serologic remission ...

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RE: Lupus - Steroid free management options 1 day ago

In my opinion , she is not in remission snd has immunologically active diseases . A repeat kidney biopsy is not needed. She is a good candidate for...

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RE: Pd Question 1 day ago

Developed ascites post transplant Transplant . Cirrhosis on us and liver team Said cirrhosis happened post transplant( no liver disease prior) ...

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RE: Recurrence of C3 Glomerulopathy After Kidney Transplantation ? 1 day ago

I think the question here is did the patient have IC- MPGN sec to lupus vs MPGN-C3 on the first biopsy. Here Pronase digestion would help to ru...

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RE: Pd Question 1 day ago

As I suspected, the , no change in GFR suggest that all of the 10 ml/min is coming from the native kidneys. I agree with draining completely and in...

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