RE: STEC-HUS in pregnancy 5 hours ago

Thanks prof glassock my experience is limited in pregnant patients with stec hus I would use it if there has been evidence of benefit ( I will loo...

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RE: Membranous Nephropathy 5 hours ago

Thanks prof glassock Sle means what sorry? --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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RE: Membranous Nephropathy 5 hours ago

This is the absolute value -in cells per microliter of blood. It is not a percentage value. Thisis the preferred target level for full B-Cell suppr...

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RE: STEC-HUS in pregnancy 5 hours ago

Dr. Soodbadar (and others) would you use PLEX or anti-C5 MoAB in this patient? ------------------------------ Richard Glassock MD, FASN Emeritus ...

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RE: Hypertension With Impaired Natriuresis 5 hours ago

Several formulas are available to estimate 24 hour urine Sodium excretion in hypertensive subjects (and thereby Sodium intake in patients with stab...

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RE: Membranous Nephropathy 6 hours ago

Thanks prof glassock You look at absolute value as well? --------------------------------- Muhammad Soobadar MBChB UK -------------------------...

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RE: STEC-HUS in pregnancy 6 hours ago

Hi tough case. It’s usually supportive treatment in non pregnant patients but if they don’t recover can consider testing for ahus. This is stec hu...

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RE: Membranous Nephropathy 6 hours ago

The target level of B cell depletion with Anti-CD20 MoAb is < 5 CD19 + cell per microliter . ------------------------------ Richard Glassock MD...

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RE: Membranous Nephropathy 6 hours ago

Thanks for case . Can I ask what is absolute cd19 and percentage cd19 we use to say b cell repopulation . I was told percentage cd19 5% or more Bw...

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RE: Encapsulating peritonitis 13 hours ago

I'm not as optimistic as Dr Rodby. Not so much about the operative mechanics of putting in a kidney but more that he has a serious comorbidity with...

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RE: Encapsulating peritonitis 13 hours ago

I suspect if he is alive he has survived this often terminal condition. You are not going to reverse the calcifications and adhesions, is he on t...

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RE: Membranous Nephropathy 14 hours ago

because you patient was on hydralazine, I would check DS DNA, C3 C4 and RF and ANCA, Hydralazine can cause drug induced GN (can look like lupus and...

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RE: Hypertension With Impaired Natriuresis 14 hours ago

In hypokalemic HTN I would start with renin and aldo and go from there. Based on that I may pursue primary hyperaldo or the syndrome of apparent al...

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RE: Hypertension With Impaired Natriuresis 14 hours ago

In regard evaluating hypertension i would say no. The low U Na suggests hypovolemia and not necessarily impaired natriuresis. In that case the U ...

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RE: Hypertension With Impaired Natriuresis 18 hours ago

https://physoc.onlinelibrary.wiley.com/doi/full/10.1113%2Fjphysiol.2014.271676 Pressure naturesis may be impaired in patients with hypertension a...

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RE: Hypertension With Impaired Natriuresis 19 hours ago

https://www.ahajournals.org/doi/10.1161/01.hyp.11.6.724 --------------------------------- Dr. Hormaz Dastoor. MD, MSc, FASN Divisional Head of Nep...

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RE: Hypertension With Impaired Natriuresis 21 hours ago

A spot urinary sodium concentration measurement is a poor reflection of sodium excretion or sodium balance, your hypothesis of impaired natriuresis...

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RE: Hypertension With Impaired Natriuresis 22 hours ago

My idea is that this test was done in a point of time when blood pressure was elevated significantly, simultaneously sodium excretion was drastical...

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RE: Hypertension With Impaired Natriuresis 22 hours ago

Clinical guidelines do not recommend routine sodium or potassium concentration on spot random urine specimens in hypertensive subjects. The results...

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RE: STEC-HUS in pregnancy 22 hours ago

------------------------------ Richard Glassock MD, FASN Emeritus Professor Geffen School of Medicine at UCLA Laguna Woods CA (949) 338-0357 ------...

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RE: Hypertension With Impaired Natriuresis 23 hours ago

A spot sodium to creatinine ratio in a spot urine collection (usually in the late afternoon before dinner) shows a better correlation to 24 hour ur...

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RE: Hypertension With Impaired Natriuresis 23 hours ago

The gold standard for assessing sodium or potassium excretion rates (and intakes) in a patient with stable body weight is a timed 24 hour urine spe...

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Hypertension With Impaired Natriuresis 23 hours ago

Just wanted to share with community, I have no. Of patients who referred to me for new onset or uncontrolled hypertension. All of them with normal ...

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RE: Membranous Nephropathy 1 day ago

Thanks for the reply Update: I had stopped hydralazine Histone Ab 1.7 High Comment: Value Explanation of Results 2.5 Str...

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RE: STEC-HUS in pregnancy 1 day ago

With bloody diarrhea and a stool culture + for E. Coli 0157 and the absence if neurological features this seems highly likely to be STEC related HU...

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RE: Fit To Fly In Ckd 5 Patient 1 day ago

Thanks everyone 🙏🏼 --------------------------------- Muhammad Soobadar MBChB UK --------------------------------- [More]

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RE: STEC-HUS in pregnancy 1 day ago

The role of C5- inhibition in STEC related HUS is highly uncertain in Pregnancy or Non pregnant patients. Eculizumab and Ravulizumab appear safe in...

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RE: STEC-HUS in pregnancy 1 day ago

am still not sure if this is STEC- HUS. The Plasmic score or even the French plasmic score , especially with your patient having a very low platele...

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RE: C3GN in the setting of melanoma 1 day ago

A monoclonal protein can cause activation of either the classical and alternate complement pathway. In your case with low C3 and normal C4 , and a...

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STEC-HUS in pregnancy 1 day ago

I have a 30 year old pregnant patient: G3P2 at 25 weeks of gestation, admitted with bloody diarrhea with stool positive for E.coli O157. Renal func...

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RE: Fit To Fly In Ckd 5 Patient 1 day ago

Poor BP control might be addressed before the flight. ------------------------------ Richard Glassock MD, FASN Emeritus Professor Geffen School o...

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RE: Fit To Fly In Ckd 5 Patient 1 day ago

So long as the patient understands that supplemental Oxygen is not available on the flight and to avoid high potassium foods during the flight, I s...

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RE: Fit To Fly In Ckd 5 Patient 1 day ago

Hb 94 around 105/110 last couple of month Not on oxygen , bp erratic from 140-170 mm hg systolic Many thanks ---------------------------------...

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RE: C3GN in the setting of melanoma 1 day ago

Very complex and rare case (perhaps one of a kind). In this case C3GN has preceded treatment with immune checkpoint inhibitors (ICI) He surely need...

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Encapsulating peritonitis 1 day ago

I have inherited a 17-year-old young man with sclerosing peritonitis. He was transplanted when he was 6; unfortunately lost his graft with recurren...

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RE: Membranous Nephropathy 1 day ago

Early return of B cells. Give another dose of OBI (1000mg) ------------------------------ Richard Glassock MD, FASN Emeritus Professor Geffen Sch...

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RE: Iptacopan in IgA 1 day ago

The hematuria declined in the first 2 months from October to Dec from 2-3 plus to 1+ or negative ..in March both patients had an increase in hematu...

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RE: Iptacopan in IgA 1 day ago

@Hormaz Dastoor: My question was regarding trend of microscopic hematuria in the 2 patients on optician. ------------------------------ K.K. Venk...

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RE: Iptacopan in IgA 1 day ago

@K.K. Venkat there was no change in proteinuria during the period of worsening proteinuria @Richard Glassock I do agree with the compliance issue...

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RE: Membranous Nephropathy 1 day ago

Thanks for the replies Received 3rd dose of Obinutuzumab on 10/21/2025 PLA2R Ab (ELISA) again increasing: 26 (10/2026) ----> 27 (4/2026) ...

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C3GN in the setting of melanoma 2 days ago

Dear Colleagues, I'd like to seek your professional opinion about the management of a patient I follow in the hospital. A 79-year-old man with a h...

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RE: Iptacopan in IgA 2 days ago

Dr. Dastoor. Thanks for this interesting post . The main reasons for discrepancies between trial data and real world experience with oral agents,...

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RE: Iptacopan in IgA 2 days ago

What is the trend of microscopic hematuria on iptacopan in these 2 patients? ------------------------------ K.K. Venkat MD Troy MI (248) 420 7798...

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RE: 28-year-old male with repaired Tetralogy of Fallot presenting with RPGN vs infective endocarditis-associated GN - immunosuppression dilemma 2 days ago

Would start broad spectrum antibiotics pending TEE and blood culture results. The decision to discontinue steroids should be made if the patient ha...

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DEADLINE EXTENDED TO MAY 11: Case Report Reviewers for Kidney Week 2026 2 days ago

ASN invites ASN Fellows-in-Training members to serve as reviewers for case reports submitted by trainees for Kidney Week 2026. The reviewing/gradin...

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DEADLINE EXTENDED TO MAY 11: Encourage fellows to volunteer as case report reviewers for Kidney Week 2026! 2 days ago

ASN invites ASN Fellows-in-Training members to serve as reviewers for case reports submitted by trainees for Kidney Week 2026. The reviewing/gradin...

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Iptacopan in IgA 2 days ago

i wanted to share the responses of 2 patients with IgA with Iptacopan Patient 1 : 42 year old male : eGFR 66 ml/min, Hematuria , uPCR > 1gram on ...

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RE: 28-year-old male with repaired Tetralogy of Fallot presenting with RPGN vs infective endocarditis-associated GN - immunosuppression dilemma 2 days ago

The "evidence" for an overall beneficial effect of adjunctive Immunosuppression in Proven Infection Related RPGN with crescents is very weak and co...

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RE: AKI/ANCA Vasculitis 2 days ago

1. Part of the confusion/complication was the infection and +anca. Unusual to have both. Infection has resolved and bladder is clear per urology. ...

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RE: Persistent Nephrotic Syndrome (IgG2-dominant MGN) , PLA2R negative 2 days ago

Thank you all for your replies Dr Reen ECA normal , non lymph nodes on CT , will see with pathologist if he can do Pronase digestion , but lambd...

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