Basic/Clinical Science Session

Metabolic Reprogramming in Polycystic Kidney Disease

November 09, 2019 | 02:00 PM - 04:00 PM

Location: 147, Walter E. Washington Convention Center

Session Description

Numerous metabolic derangements have been described in PKD, including aerobic glycolysis and impairment in fatty acid oxidation and the citric acid cycle. Recent studies suggest that polycystin-1 regulates mitochondrial structure and function. Abnormalities in nutrient sensing and AMP kinase have also been reported. This session discusses controversies in the field and identify targets for therapeutic interventions.

Learning Objective(s)

  • Identify the metabolic abnormalities in PKD
  • Describe how advances in metabolomics can advance understanding of cellular metabolism
  • Explain why drugs such as metformin may be useful in the treatment of PKD

Learning Pathway(s)

  • Genetic Diseases of the Kidneys
  • Diabetes and Metabolism

Moderators

  • Michael J. Caplan, MD, PhD
  • Ronak Lakhia, MD

Presentations

  • Rewiring the Citric Acid Cycle in PKD
    02:00 PM - 02:30 PM
    Alessandra Boletta, PhD
  • Polycystins Regulate Mitochondrial Metabolism
    02:30 PM - 03:00 PM
    Gregory G. Germino, MD
  • AMPK: A Therapeutic Target in ADPKD
    03:00 PM - 03:30 PM
    York P. Pei, MD, FASN
  • Targeting Metabolism to Treat PKD
    03:30 PM - 04:00 PM
    Kenneth R. Hallows, MD, PhD, FASN