ASN President's Medal, ASN President's Address, State-of-the-Art Lecture, Featured High-Impact Clinical Trials Note: Continuing education credits are not being offered for this session.
Poster will be posted on October 2. Note: Continuing education credits are not being offered for these sessions.
Exhibitor Spotlights (10:15-1:45)
An understanding of human development informs efforts to generate functional human kidney cell types. Interactions among distinct progenitors drive human kidney development. This session highlights nephron and ureteric progenitors of the kidneys' nephron and collecting system, respectively. Speakers discuss molecular and cellular m...
The field of kidney transplantation spans all aspects of nephrology care, from advances in pathology and immunology to AKI and CKD management to health care delivery and policy. Experts in the field present the most important advances in kidney transplantation, as reflected in recent publications, and offer the opportunity to vote ...
The last five years have seen a seismic shift in clinical trial activity in glomerular diseases, with many trials reporting positive results and new drugs being approved. These successes are now challenging how we design and deliver clinical trials in glomerular diseases, as traditional placebo-controlled trial designs are increasi...
The kidneys play a critical role in maintaining homeostasis. Thus, the pathophysiology and treatment of electrolyte and acid-base disorders differ significantly in patients with advanced kidney diseases or receiving dialysis. This session discusses selected electrolyte, acid-base, and metabolic disorders in this patient population ...
Adults with CKD tend to have low levels of physical activity and high levels of sedentary behavior. These modifiable behaviors can influence health and well-being. This session discusses interventions to reduce sedentary behavior, increase physical activity, and promote exercise, and it explores the benefits of increased physical a...
This session describes various practice enhancements to optimize care for people living with diabetes and CKD, including involving pharmacists, partnering with primary care and the community, and leveraging patient support organizations.
Despite advances in pediatric kidney transplantation, access and long-term outcomes still fall short. This session addresses emerging barriers to and implications for pediatric kidney transplant access, as well as the effects of therapeutic approaches on long-term outcomes. Speakers present new data on maintenance immunosuppression...
This session highlights challenges and opportunities in the field of hemodialysis vascular access, including identification of gaps in knowledge and training, and proposed solutions to overcome these barriers. The session also describes updates in the management of complex hemodialysis vascular access, with an emphasis on translati...
The search for accurate biomarkers in CKD is challenging. Disease modifiers may interfere in an already complex landscape. This session focuses on factors that could improve the evaluation of disease outcomes and conditions that affect cardiovascular disease, mineral metabolism, and CKD risk. Particular attention is given to CKD st...
This session explores the renewed momentum to implement AKI biomarkers in routine clinical care, driven by recent evidence from studies. The session examines how biomarkers can enhance perioperative risk classification, improve prognostic assessment during and after AKI, and enable biologically grounded endophenotyping that may ult...
The FIT Bowl will take place in the Futures Theater in the Exhibit Hall. Note: Continuing education credits are not being offered for this activity.
Potassium homeostasis is an essential component of kidney function, and hyperkalemia is common in individuals with declining kidney function. Hyperkalemia poses clinical challenges because it can affect dietary and medication options in patients with CKD and cardiac dysfunction and may lead to withdrawal of agents that are otherwis...
Kidney functions reflect the interplay among diverse cell types, posing challenges for in vitro modeling and tissue replacement. Cell diversity reflects the kidneys' multilineage origin and lineage-specific developmental programs driven by cell interactions within and across lineages. Experts address, assess, and critique advanced ...
Obesity and CKD are interrelated. With the rapid uptake of GLP-1 receptor agonists (RAs), used alone or in combination with other therapeutic approaches, for the management of patients with obesity and CKD, clinicians face practical issues related to safety, treatment combinations, complications, and discontinuation of therapy. Thi...
The cell cytoskeleton does more than provide a cellular scaffold in dynamic environments. This session examines how modulators of the cell cytoskeleton and mechanosensors can facilitate regeneration or promote further injury, thereby contributing to CKD progression after cellular stressors. Cutting-edge research is presented that e...
The glomerulus is a dynamic community in which podocytes, endothelial cells, mesangial cells, and immune cells constantly exchange signals that shape filtration and resilience. In diseases such as IgAN and diabetic kidney disease, this communication becomes distorted, amplifying injury and driving progression. This session explores...
Metabolic dysfunction in diabetic kidney disease (DKD) extends beyond hyperglycemia to encompass profound rewiring of cellular fuel use and stress responses. This session explores how tubular epithelial cells shift from fatty acid oxidation toward glycolysis, lactate accumulation, and altered amino acid metabolism, creating vulnera...
This session focuses on key molecular discoveries that have advanced our understanding of tubular transport in the nephrons. Experts emphasize clinical relevance and explain how new insights complement prior assumptions and clinical care.
Currently, no effective therapies robustly enhance the kidneys' resilience to AKI, a critical unmet clinical need. This session explores recently identified cellular and molecular processes that underpin renal homeostasis and the kidneys' resilience to injury and their role in progression to CKD. Additionally, an innovative genetic...
Artificial intelligence (AI) is increasingly used in medicine, but most tools are built for one single, narrow task at a time. Foundation models are different. They first learn the basic "language" of a system and can then apply it to many problems. In kidney research, a foundation model can learn core kidney biology by integrating...
Frailty and aging are increasingly recognized as biological states that reshape immune function and transplant outcomes beyond chronological age. Emerging evidence links immunosenescence, inflammaging, altered T-cell maturation, and organ-intrinsic biological aging to heterogeneity in alloimmune responses and graft vulnerability. T...
As the population of patients living with cancer continues to grow and survive longer, kidney diseases in oncology have become increasingly common, complex, and clinically significant. This clinical practice session provides a case-based, evidence-driven update on key challenges at the intersection of nephrology and oncology, with ...
With the rapidly changing management landscape for glomerular diseases, this session reviews current challenges in diagnosis, prognostication, and treatment, with a particular focus on the roles of genetic testing and kidney biopsy in diagnosis and their potential future role in treatment selection. Future advances in risk stratifi...
Demand for dialysis is expected to significantly increase globally in the future. Home dialysis, including peritoneal dialysis (PD) and home hemodialysis, is a key strategy to address this need. This session emphasizes the importance of understanding the barriers to increasing home dialysis use and discusses strategies to facilitat...
This session presents current and emerging issues that patients face. Patients and medical and research professionals describe working together to implement current and new initiatives and to recommend greater patient involvement in research, policies, and procedures. The panel examines methods to find common ground to advance outc...
Kidney biopsy is required to diagnose most glomerular diseases. However, a kidney biopsy may not be required to diagnose PLA2R-associated membranous nephropathy. The role of protocol and repeat kidney biopsies in IgAN, lupus nephritis, and ANCA-associated vasculitis is also controversial. The session addresses the role of repeat an...
Patients with advanced kidney diseases face a disproportionate burden of neurologic and cardiovascular complications that are often underrecognized and challenging to manage. This session reviews stroke, myocardial infarction, sudden cardiac death prevention, and peripheral artery disease in this high-risk population. Practical ins...
Robust clinical trial evidence to guide treatments for preventing kidney stone diseases and pathological vascular calcification has been relatively sparse. Several important studies have helped fill this gap in recent years. This session describes a large, randomized study of kidney stones, groundbreaking treatments for primary hyp...
There is a shortage of nephrology providers and declining interest in nephrology fellowship programs. This session addresses nephrology workforce concerns and explores strategies to promote recruitment into nephrology, the role of advanced practice providers (APPs) in nephrology, and the pediatric nephrology workforce.
This session addresses the management of medical conditions common among patients receiving dialysis and considerations for applying, in the setting of kidney failure, treatments or approaches known to be effective in the general population. Experts focus on new treatments and review evidence for or against their use in dialysis-de...
Advances in research are yielding innovative therapies for both rare and common kidney diseases at an unprecedented pace. But true progress is measured by patient access and use, not just approval. This session examines the complex barriers to the broad distribution of newly approved therapies for glomerular diseases, including exp...
Hemoadsorption is an emerging extracorporeal therapy that removes inflammatory mediators, endotoxins, and select circulating compounds from critically ill patients. This session reviews the mechanisms of hemoadsorption and critically examines clinical evidence for its use in cardiac surgery-associated AKI, endotoxic septic shock, a...
Oral abstract sessions will be posted on October 2. Note: Continuing education credits are not being offered for these sessions.
