Translational Session

Complement Complement Everywhere: What Does It All Mean?

November 08, 2019 | 04:30 PM - 06:30 PM

Location: Ballroom A, Walter E. Washington Convention Center

Session Description

The complement system has been implicated in a number of renal disorders, but its role in podocyte injury and glomerular disease remains unclear. Several complement targeting therapeutics are in use with many more in development. This session summarizes the knowledge to date of the role of complement in glomerular disease pathogenesis, highlighting a potential role for anticomplement therapy.

Learning Objective(s)

  • Define the pathogenic role of complement in non-antibody mediated kidney disease
  • Describe the molecular features of complement activation in pauci-immune glomerulonephritis
  • Discuss the mechanistic rationale for complement targeting therapy in glomerular disease
  • Describe the association between complement system regulation and thrombotic microangiopathy

Learning Pathway(s)

  • Glomerular Diseases
  • Pathology

Moderator(s)

  • Paolo Cravedi, MD, PhD
  • Nicole Van De Kar, MD, PhD

Presentations

  • Pathogenesis of Complement-Mediated Podocyte Injury in FSGS
    04:30 PM - 05:00 PM
    Joshua M. Thurman, MD
  • Complement in Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy
    05:00 PM - 05:30 PM
    Craig B. Langman, MD
  • Complement in IgA Nephropathy
    05:30 PM - 06:00 PM
    Jonathan Barratt, MBChB, PhD
  • Complement in Pauci-Immune Glomerulonephritis
    06:00 PM - 06:30 PM
    David R.W. Jayne, MD, MBChB