Basic/Clinical Science Session

"Mighty" Chondrion: More than the Powerhouse of the Cell

November 07, 2019 | 04:30 PM - 06:30 PM

Location: Ballroom B, Walter E. Washington Convention Center

Session Description

The kidneys are rich in mitochondria and derive most of their energy from oxidative metabolism. In addition to ATP generation, mitochondria play a significant role in the generation and detoxification of reactive oxygen species, cellular calcium homeostasis, and cell survival and death. These dynamic organelles respond to the changing energy demands of the cells and play a key role in the adaptation to cellular stress. There is new literature about the role of mitochondrial dysfunction in the early stages of both AKI and CKD. Changes in mitochondrial biogenesis, energetics, and dynamics appear to play a pathogenic role in kidney diseases.

Learning Objective(s)

  • Describe leading and emerging research in the role of mitochondrial function in AKI and CKD
  • Explain the role of mitochondrial dynamics and autophagy (mitophagy) in mitochondrial quality control in tubular injury
  • Discuss recent developments in understanding mitochondrial biogenesis and bioenergetics in kidney injury

Learning Pathway(s)

  • Acute Kidney Injury
  • Chronic Kidney Disease

Moderators

  • Sarah C. Huen, MD, PhD
  • Sandeep K. Mallipattu, MD, FASN

Presentations

  • Mitochondrial Bioenergetics in Kidney Diseases
    04:30 PM - 05:00 PM
    Prabhleen Singh, MD, MPH
  • Mitochondrial Biogenesis in AKI
    05:00 PM - 05:30 PM
    Mei T. Tran
  • Mitochondrial Quality Control in AKI
    05:30 PM - 06:00 PM
    Zheng Dong, PhD, FASN
  • Determinants of Mitochondrial Function in Septic AKI
    06:00 PM - 06:30 PM
    Mary E. Choi, MD