Basic/Clinical Science Session

Kidney, Bone, and Vasculature: Is the Gut a New Piece of the Puzzle?

November 09, 2019 | 10:30 AM - 12:30 PM

Location: 145, Walter E. Washington Convention Center

Session Description

Patients with CKD exhibit a disproportionate burden of cardiovascular mortality, which likely stems from the presence of unique, nontraditional risk factors that accompany deteriorating kidney function. Mounting evidence suggests that alterations to the intestinal microbiome in CKD may serve as one such risk factor.

Learning Objective(s)

  • Describe the microbiome-mediated mechanisms associated with CKD-MBD
  • Discuss how intestinal barrier dysfunction leads to bacterial translocation and endotoxemia that potentiate systemic inflammation
  • Describe the accumulation of dietary-derived bacterial byproducts that stimulate pathways promoting atheromatous changes in arteries and cardiovascular disease

Learning Pathway(s)

  • Bone and Mineral Metabolism


  • Linda F. Fried, MD, MPH, FASN
  • Dominic S. Raj, MD, MBBS, FASN