Beating the Law of Averages: Predicting Diabetic Kidney Disease Outcomes Through Integrative Biology
November 10, 2019 | 10:00 AM - 12:00 PM
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Basic/Clinical Science Session
Beating the Law of Averages: Predicting Diabetic Kidney Disease Outcomes Through Integrative Biology
November 10, 2019 | 10:00 AM - 12:00 PM
Location: 145, Walter E. Washington Convention Center
Session Description
The complex heterogeneous nature of diabetes (nutritional, environmental, and maternal factors), and their impact on kidney structure and function in health and disease states, requires a cell lineage-specific interrogation and integration to understand underpinning biological mechanisms. This session highlights clinical ultrastructural determinants of diabetic kidney disease progression and links them with environmental and epigenetic factors through novel analytical pipelines
Learning Objective(s)
- Describe kidney ultrastructure and the determinants of renal disease progression in diabetes
- Identify the role of single cell analysis and integration in discovering mechanisms
- Discuss the role of organoids in defining disease pathways
- Identify key regulatory elements linking maternal nutrition to nephron endowment
Learning Pathway(s)
- Diabetes and Metabolism
- Glomerular Diseases
Moderators
- Jennifer L. Harder, MD
- Rama Natarajan, PhD, FASN
Presentations
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Morphogenomics: Lessons from Southwestern American Indian Longitudinal Studies
10:00 AM - 10:30 AM
Robert G. Nelson, MD, PhD, FASN
Robert G. Nelson, MD, PhD, FASN
Morphogenomics: Lessons from Southwestern American Indian Longitudinal Studies
November 10, 2019 | 10:00 AM - 10:30 AM
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Unravelling Molecular Mechanisms of Diabetic Kidney Disease for Therapeutic Target Characterization
10:30 AM - 11:00 AM
Matthias Kretzler, MD
Unravelling Molecular Mechanisms of Diabetic Kidney Disease for Therapeutic Target Characterization
November 10, 2019 | 10:30 AM - 11:00 AM
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DNA Methylation, Maternal Nutrition, and Prenatal Renal Programming
11:00 AM - 11:30 AM
Tobias B. Huber, MD, FASN
Tobias B. Huber, MD, FASN
DNA Methylation, Maternal Nutrition, and Prenatal Renal Programming
November 10, 2019 | 11:00 AM - 11:30 AM
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Kidney Organoids, Gene Editing, and Multidimensional Phenotyping
11:30 AM - 12:00 PM
Benjamin S. Freedman, PhD
Benjamin S. Freedman, PhD
Kidney Organoids, Gene Editing, and Multidimensional Phenotyping
November 10, 2019 | 11:30 AM - 12:00 PM
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