Beating the Law of Averages: Predicting Diabetic Kidney Disease Outcomes Through Integrative Biology
November 10, 2019 | 10:00 AM - 12:00 PM
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Basic/Clinical Science Session
Beating the Law of Averages: Predicting Diabetic Kidney Disease Outcomes Through Integrative Biology
November 10, 2019 | 10:00 AM - 12:00 PM
Location: 145, Walter E. Washington Convention Center
Session Description
The complex heterogeneous nature of diabetes (nutritional, environmental, and maternal factors), and their impact on kidney structure and function in health and disease states, requires a cell lineage-specific interrogation and integration to understand underpinning biological mechanisms. This session highlights clinical ultrastructural determinants of diabetic kidney disease progression and links them with environmental and epigenetic factors through novel analytical pipelines
Learning Objective(s)
- Describe kidney ultrastructure and the determinants of renal disease progression in diabetes
- Identify the role of single cell analysis and integration in discovering mechanisms
- Discuss the role of organoids in defining disease pathways
- Identify key regulatory elements linking maternal nutrition to nephron endowment
Learning Pathway(s)
- Diabetes and Metabolism
- Glomerular Diseases
Moderators
- Jennifer L. Harder, MD
- Rama Natarajan, PhD, FASN
Presentations
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Morphogenomics: Lessons from Southwestern American Indian Longitudinal Studies
10:00 AM - 10:30 AM
Frank C. Brosius, MD
Frank C. Brosius, MD
Dr. Brosius is a professor of medicine and interim chief of nephrology at the University of Arizona, and is an active professor emeritus at the University of Michigan. His research focuses on identification of new targets for treatment of diabetic kidney disease (DKD). One such target identified by his colleagues and him was the JAK/STAT signaling pathway. A phase 2 clinical trial, co-led by Dr. Brosius and Dr. Kathy Tuttle, showed that a JAK inhibitor led to reduced albuminuria in patients with DKD. He currently is a principal investigator on a multi-PI NIH R24 grant to identify additional targets for intervention in kidney, nerve and eye complications of diabetes. He is also involved in a number of clinical studies targeting DKD and other chronic kidney diseases. He has served and continues to serve on multiple committees and working groups related to his clinical and research interests with the American Society of Nephrology, National Kidney Foundation, American Heart Association and American Diabetes Association.
Morphogenomics: Lessons from Southwestern American Indian Longitudinal Studies
November 10, 2019 | 10:00 AM - 10:30 AM
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Unravelling Molecular Mechanisms of Diabetic Kidney Disease for Therapeutic Target Characterization
10:30 AM - 11:00 AM
Matthias Kretzler, MD
Unravelling Molecular Mechanisms of Diabetic Kidney Disease for Therapeutic Target Characterization
November 10, 2019 | 10:30 AM - 11:00 AM
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DNA Methylation, Maternal Nutrition, and Prenatal Renal Programming
11:00 AM - 11:30 AM
Tobias B. Huber, MD, FASN
Tobias B. Huber, MD, FASN
DNA Methylation, Maternal Nutrition, and Prenatal Renal Programming
November 10, 2019 | 11:00 AM - 11:30 AM
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Kidney Organoids, Gene Editing, and Multidimensional Phenotyping
11:30 AM - 12:00 PM
Benjamin S. Freedman, PhD
Benjamin S. Freedman, PhD
Kidney Organoids, Gene Editing, and Multidimensional Phenotyping
November 10, 2019 | 11:30 AM - 12:00 PM
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