Basic/Clinical Science Session

Beating the Law of Averages: Predicting Diabetic Kidney Disease Outcomes Through Integrative Biology

November 10, 2019 | 10:00 AM - 12:00 PM

Location: 145, Walter E. Washington Convention Center

Session Description

The complex heterogeneous nature of diabetes (nutritional, environmental, and maternal factors), and their impact on kidney structure and function in health and disease states, requires a cell lineage-specific interrogation and integration to understand underpinning biological mechanisms. This session highlights clinical ultrastructural determinants of diabetic kidney disease progression and links them with environmental and epigenetic factors through novel analytical pipelines

Learning Objective(s)

  • Describe kidney ultrastructure and the determinants of renal disease progression in diabetes
  • Identify the role of single cell analysis and integration in discovering mechanisms
  • Discuss the role of organoids in defining disease pathways
  • Identify key regulatory elements linking maternal nutrition to nephron endowment

Learning Pathway(s)

  • Diabetes and Metabolism
  • Glomerular Diseases


  • Jennifer L. Harder, MD
  • Rama Natarajan, PhD, FASN