Kidney Week

Basic/Clinical Science Session

Beating the Law of Averages: Predicting Diabetic Kidney Disease Outcomes Through Integrative Biology

November 10, 2019 | 10:00 AM - 12:00 PM

Location: 145, Walter E. Washington Convention Center

Session Description

The complex heterogeneous nature of diabetes (nutritional, environmental, and maternal factors), and their impact on kidney structure and function in health and disease states, requires a cell lineage-specific interrogation and integration to understand underpinning biological mechanisms. This session highlights clinical ultrastructural determinants of diabetic kidney disease progression and links them with environmental and epigenetic factors through novel analytical pipelines

Learning Objective(s)

• Describe kidney ultrastructure and the determinants of renal disease progression in diabetes
• Identify the role of single cell analysis and integration in discovering mechanisms
• Discuss the role of organoids in defining disease pathways
• Identify key regulatory elements linking maternal nutrition to nephron endowment

Learning Pathway(s)

• Diabetes and Metabolism
• Glomerular Diseases

Moderators

• Jennifer L. Harder, MD
• Rama Natarajan, PhD, FASN

Presentations

• Morphogenomics: Lessons from Southwestern American Indian Longitudinal Studies
  10:00 AM - 10:30 AM
  Frank C. Brosius, MD 
  
  

  Frank C. Brosius, MD

  Dr. Brosius is a professor of medicine and interim chief of nephrology at the University of Arizona, and is an active professor emeritus at the University of Michigan. His research focuses on identification of new targets for treatment of diabetic kidney disease (DKD). One such target identified by his colleagues and him was the JAK/STAT signaling pathway. A phase 2 clinical trial, co-led by Dr. Brosius and Dr. Kathy Tuttle, showed that a JAK inhibitor led to reduced albuminuria in patients with DKD. He currently is a principal investigator on a multi-PI NIH R24 grant to identify additional targets for intervention in kidney, nerve and eye complications of diabetes. He is also involved in a number of clinical studies targeting DKD and other chronic kidney diseases. He has served and continues to serve on multiple committees and working groups related to his clinical and research interests with the American Society of Nephrology, National Kidney Foundation, American Heart Association and American Diabetes Association.

Morphogenomics: Lessons from Southwestern American Indian Longitudinal Studies

November 10, 2019 | 10:00 AM - 10:30 AM

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• Unravelling Molecular Mechanisms of Diabetic Kidney Disease for Therapeutic Target Characterization
  10:30 AM - 11:00 AM
  Matthias Kretzler, MD
  

  Matthias Kretzler, MD

Unravelling Molecular Mechanisms of Diabetic Kidney Disease for Therapeutic Target Characterization

November 10, 2019 | 10:30 AM - 11:00 AM

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• DNA Methylation, Maternal Nutrition, and Prenatal Renal Programming
  11:00 AM - 11:30 AM
  Tobias B. Huber, MD, FASN
  

  Tobias B. Huber, MD, FASN

DNA Methylation, Maternal Nutrition, and Prenatal Renal Programming

November 10, 2019 | 11:00 AM - 11:30 AM

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• Kidney Organoids, Gene Editing, and Multidimensional Phenotyping
  11:30 AM - 12:00 PM
  Benjamin S. Freedman, PhD
  

  Benjamin S. Freedman, PhD

Kidney Organoids, Gene Editing, and Multidimensional Phenotyping

November 10, 2019 | 11:30 AM - 12:00 PM

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