Kidney Week

Translational Session

Sex and Hypertension

November 08, 2019 | 10:30 AM - 12:30 PM

Location: 202, Walter E. Washington Convention Center

Session Description

Hypertension is the leading risk factor for cardiovascular disease. More women have hypertension with aging than men, and more women die from CVD than men. This session discusses new insights into why postmenopausal women may have increased incidence of hypertension.

Learning Objective(s)

• Describe potential mechanisms responsible for hypertension after menopause
• Explain how periodontal disease, early senescence, and endothelin may affect hypertension in women
• Describe the sex differences in hypertension in response to androgens
• Summarize new discoveries in obesity-related hypertension that differ between men and women

Learning Pathway(s)

• Hypertension and CVD

Moderators

• Andrea G. Kattah, MD, MS
• Jane F. Reckelhoff, PhD

Presentations

• Sex Differences in Periodontal Disease and Cardiorenal Syndrome
  10:30 AM - 11:00 AM
  Kristine Y. DeLeon-Pennell, PhD 
  
  

  Kristine Y. DeLeon-Pennell, PhD

  Dr. DeLeon-Pennell was trained in cardiovascular sciences at Baylor University, University of Texas Health Science Center San Antonio, and the University of Mississippi Medical Center. She has >10 years’ experience with all aspects of the inflammatory and fibrotic components of cardiac remodeling following myocardial infarction (MI). In particular, she has extensive training in matrix metalloproteinase (MMP) biology, extracellular matrix remodeling, and cellular physiology research with an emphasis in sex differences.

Sex Differences in Periodontal Disease and Cardiorenal Syndrome

November 08, 2019 | 10:30 AM - 11:00 AM

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• Senescence-Associated Secretory Phenotype and Hypertension in Postmenopausal Women
  11:00 AM - 11:30 AM
  Vesna D. Garovic, MD, PhD 
  
  

  Vesna D. Garovic, MD, PhD

  Dr. Garovic is Professor of Medicine, Mayo Clinic Rochester, Minnesota, and holds joint appointments in Nephrology and Obstetrics and Gynecology. She currently serves as Chair for Research, Division of Nephrology and Hypertension, Vice-Chair for Research, Department of Internal Medicine, and as Director, Clinical Research Office and Office of Clinical Trials, Department of Medicine, Mayo Clinic. Her journal editorial responsibilities include Editor-in-Chief for Hypertension in Pregnancy, Associate Editor and Section editor for Women's Health and Medicine of Sex Differences, Mayo Clinic Proceedings, Section editor, Preeclampsia for Current Hypertension Reports, and editorial board member, Kidney International. She has a long standing interest in studying renal disease and hypertension in pregnancy, the pathophysiology of hypertensive pregnancy disorders and, specifically, preeclampsia, and has published over 150 peer-reviewed papers. Her clinical and research interests in hypertensive pregnancy disorders preeclampsia span several research areas: diagnosis and treatment of hypertension in pregnancy, underlying molecular mechanisms of renal injury, epigenetics, and epidemiology of long-term cardiovascular and renal effects, with the long-term objective of identifying diagnostic biomarkers and potential new therapeutic targets in order to improve immediate and long-term outcomes of this enigmatic disease.

Senescence-Associated Secretory Phenotype and Hypertension in Postmenopausal Women

November 08, 2019 | 11:00 AM - 11:30 AM

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• Sex Differences in Obesity-Related Hypertension
  11:30 AM - 12:00 PM
  Eric J. Belin de chantemele, MS, PhD 
  
  

  Eric J. Belin de chantemele, MS, PhD

  Eric. J. Belin de Chantemele, D.Sc, FAHA, is an Assistant Professor in the Vascular Biology Center at the Medical College of Georgia at Augusta University. He received his doctoral degree from the University Claude Bernard Lyon 1, in France and followed his training by 2 postdoctoral positions, one in the University of Angers, France and a second one in the Vascular Biology Center, at Augusta University. He joined the faculty at MCG in 2011. Since then his research program has focused on investigating the mechanisms whereby obesity leads to hypertension in males and females. His work lead to the discovery that the adipokine leptin is a new direct regulator of aldosterone production, demonstrated that progesterone predisposes females to obesity-associated vascular dysfunction by upregulating endothelial mineralocorticoid receptor expression. His work also led to the proposal of the new concept that obesity leads to hypertension via sex-specific mechanisms: leptin mediated sympathoactivation in males and leptin-induced aldosterone production in females.

Sex Differences in Obesity-Related Hypertension

November 08, 2019 | 11:30 AM - 12:00 PM

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• Sex Differences in Hypertension Associated with Excess Androgen States
  12:00 PM - 12:30 PM
  Licy Yanes Cardozo, MD 
  
  

  Licy Yanes Cardozo, MD

  Licy L. Yanes Cardozo, MD, is an Associate Professor in the Departments of Cell and Molecular Biology and Medicine/Endocrinology at the University of Mississippi Medical Center. She received her Medical Degree at the National University of Asuncion (Paraguay) and performed the residency in Internal Medicine at the same institution. Later on, she performed postdoctoral studies studying the mechanisms by which androgens regulate blood pressure under the mentorship of Dr. Jane Reckelhoff at the Department of Physiology and Biophysics at the University of Mississippi Medical Center. She then completed the residency in Internal Medicine and fellowship in Endocrinology at the same institution. Currently, she is a physician-scientist engaged in basic research, clinical practice and her family. Her research focus on the elucidation of the role and mechanisms by which androgen excess mediates cardiovascular and metabolic diseases in women. She has published over 40 original manuscripts and book chapters. She has been funded by the American Heart Association, Endocrine Fellows Foundation and National Institutes of Health.

Sex Differences in Hypertension Associated with Excess Androgen States

November 08, 2019 | 12:00 PM - 12:30 PM

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