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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Clinical Practice Session

Dysproteinemic Renal Disease

November 08, 2019 | 10:30 AM - 12:30 PM

Location: 201, Walter E. Washington Convention Center

Session Description

Dysproteinemia is associated with a diverse spectrum of renal conditions, the most established of which are light-chain cast nephropathy, light-chain deposition disease, and light-chain amyloidosis. This session focuses on clinical, pathologic, and pathophysiologic aspects of dysproteinemic renal disease, as well as the expanding spectrum of monoclonal gammopathy of renal significance.

Learning Objective(s)

  • Discuss new, more sensitive assays to detect circulating monoclonal proteins and implications for assessing outcomes
  • Identify the mechanisms by which monoclonal light chains induce damage to the kidney
  • Describe the latest findings in myeloma cast nephropathy
  • Explain how C3 glomerulopathy can be considered a form of monoclonal gammopathy of renal significance

Learning Pathway(s)

  • Pathology
  • Acute Kidney Injury


  • Samih H. Nasr, MD
  • Maria M. Picken, MD, PhD, FASN


  • How Light Chains Damage Kidneys
    10:30 AM - 11:00 AM
    Paul W. Sanders, MD 
  • Clinical-Pathologic Correlations in Light Chain Cast Nephropathy
    11:00 AM - 11:30 AM
    Virginie Royal, MD 
  • New Assays to Detect Clones in Patients with Monoclonal Gammopathy of Renal Significance and New Implications
    11:30 AM - 12:00 PM
    Nelson Leung, MD 
  • C3 Glomerulopathy and Monoclonal Gammopathy of Renal Significance
    12:00 PM - 12:30 PM
    Frank Bridoux, MD, PhD