ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Genes, Epigenetics, and Tubule Transport

November 09, 2019 | 04:30 PM - 06:30 PM

Location: 146 C, Walter E. Washington Convention Center

Session Description

Cellular functions are determined by genetic variants, their effects on tissue protein expression, and the modulation of transcription and translation by epigenetic regulators. This session highlights recent discoveries in the genomic and epigenetic regulation of renal tubule function and their importance for normal renal physiology and kidney diseases.

Learning Objective(s)

  • Explain the role of ATP-binding cassette (ABC) transporters in urate transport and gout risk
  • Describe how regulation of microRNAs alters renal function
  • Discuss the role of histone deacetylases and post-translational modifications of proteins in the regulation of water balance
  • Describe the role of single cell sequencing in elucidating tubule function

Learning Pathway(s)

  • Cell and Transport Physiology


  • Vishal Patel, MD
  • Reena Rao, PhD


  • Genetics of Renal Urate Transport and Gout
    04:30 PM - 05:00 PM
    Owen M. Woodward, PhD 
  • Aldosterone Signaling and Sodium Transport: Role of MicroRNAs
    05:00 PM - 05:30 PM
    Michael Butterworth, PhD 
  • Histone and Protein Acetylation in Aquaporin Regulation and Function
    05:30 PM - 06:00 PM
    Kelly A. Hyndman, PhD 
  • Insights into Collecting Duct Biology from Transcriptomics and Single Cell Sequencing
    06:00 PM - 06:30 PM
    Mark A. Knepper, MD, PhD