ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Embedded Pragmatic Clinical Trials: Accelerating Evidence Generation in Nephrology

November 08, 2019 | 02:00 PM - 04:00 PM

Location: Salon A/B, Walter E. Washington Convention Center

Session Description

This session provides an introduction to concepts in the design, conduct, and implementation of embedded pragmatic clinical trials (ePCTs), with a focus on interventions that are relevant to the nephrology research community. These trials have the potential to inform policy and practice with broadly generalizable, high-quality evidence at a reduced cost and increased efficiency compared with traditional explanatory clinical trials. ePCT strategies provide unique opportunities for clinical investigators.

Learning Objective(s)

  • Clarify the definition of pragmatic clinical trials and explain their utility
  • Describe the unique characteristics and challenges of designing, conducting, and implementing ePCTs within diverse healthcare systems that provide care to patients with kidney diseases
  • Discuss the capacity of nephrology investigators to address important clinical questions with ePCTs

Learning Pathway(s)

  • Other


  • Susan R. Mendley, MD
  • Catherine M. Meyers, MD


  • Opportunities for Embedded Pragmatic Clinical Trials in Nephrology
    02:00 PM - 02:30 PM
    Laura M. Dember, MD, FASN
  • Design and Analysis: Strategies for Embedded Pragmatic Clinical Trials
    02:30 PM - 03:00 PM
    Qilu Yu, PhD
  • Engaging Stakeholders and Aligning with Health System Partners
    03:00 PM - 03:30 PM
    Miguel A. Vazquez, MD, FASN 
  • Designing for Post-Trial Implementation
    03:30 PM - 04:00 PM
    Wynne E. Norton, PhD