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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Cellular Mechanisms Leading to Kidney Damage in ANCA Vasculitis

October 25, 2020 | 10:00 AM - 12:00 PM

Location: On-Demand

Session Description

Innate and adaptive immune cells both contribute to inflammation and kidney damage in ANCA vasculitis. This session discusses recent advances in identifying cell types and disease mechanisms that are central to ANCA-mediated crescentic glomerulonephritis. Particular focus is given to neutrophils, monocytes, lymphocytes, and cells that are essential for crescent formation. Potential therapeutic strategies that target immune cells to induce tolerance are also discussed.

Learning Objective(s)

  • Describe the current concepts of how myeloid cells and lymphocytes invade the kidney and cause tissue injury that culminates in glomerular and interstitial inflammation
  • Define cells and mechanisms that contribute to crescent formation
  • Explain tolerance-inducing strategies in ANCA vasculitis

Learning Pathway(s)

  • Glomerular Diseases
  • Pathology


  • Donna O. Bunch, PhD
  • Ralph Kettritz, MD, FASN


  • ANCA Vasculitis: It's All About Innate Immunity
    10:00 AM - 10:30 AM
    Adrian Schreiber, MD, DrMed
  • ANCA Vasculitis: It's All About Adaptive Immunity
    10:30 AM - 11:00 AM
    Ulf Panzer, MD 
  • What It Takes to Form a Crescent
    11:00 AM - 11:30 AM
    Marcus J. Moeller, MD
  • Becoming More Tolerant to ANCA Autoantigens
    11:30 AM - 12:00 PM
    A. Richard Kitching, MBChB, PhD, FASN