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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Targeting Immunity and Inflammation in Polycystic Kidney Disease

October 24, 2020 | 10:00 AM - 12:00 PM

Location: On-Demand

Session Description

Polycystic kidney disease (PKD) is associated with significant interstitial inflammation. Abnormalities in both innate and adaptive immunity have been described and may play a role in cyst progression. This session reviews the roles of macrophages and T cells in PKD and describes how activation of injury and repair pathways contributes to disease progression.

Learning Objective(s)

  • Describe the abnormalities in innate and adaptive immunity in PKD
  • Discuss the role of resident macrophages in cyst progression
  • Outline the recently discovered role of T cells in PKD
  • Describe how renal injury and repair contribute to PKD progression

Learning Pathway(s)

  • Genetic Diseases of the Kidneys
  • Development and Pediatrics


  • Michal Mrug, MD
  • Jing Zhou, MD, PhD, FASN


  • Abnormalities of Innate Immunity in PKD
    10:00 AM - 10:30 AM
    Lloyd G. Cantley, MD, FASN 
  • Resident Macrophages in PKD
    10:30 AM - 11:00 AM
    Kurt Zimmerman, PhD
  • Role of T Cells in Cyst Progression
    11:00 AM - 11:30 AM
    Katharina Hopp, PhD 
  • Activation of Injury and Repair Pathways in PKD
    11:30 AM - 12:00 PM
    Dorien J.M. Peters, PhD