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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Membranous Nephropathy: Management in the Era of Autoantibodies

October 25, 2020 | 10:30 AM - 12:30 PM

Location: Live-Streamed

Session Description

Primary membranous nephropathy is associated with several autoantibodies that facilitate the diagnostic procedure and possibly guide treatment. This session discusses the significance of autoantibodies and kidney biopsy in managing patients with membranous nephropathy. Treatment indications and protocols and how animal models can possibly reveal novel mechanistic insight are also reviewed.

Learning Objective(s)

  • Consolidate knowledge about the occurrence of autoantibodies (e.g., to PLA2R, THSD7A, exostosin) in membranous nephropathy, their molecular structure, and immunologic dynamics
  • Define the role of a kidney biopsy in patients who are PLA2R antibody-positive
  • Describe the best available treatment and the right time point during disease course
  • Interpret animal models to understand disease mechanisms in membranous nephropathy

Learning Pathway(s)

  • Glomerular Diseases
  • Pathology


  • Laurence H. Beck, MD, PhD
  • Megan Griffith, MA, MBChB, PhD


  • Autoantibodies in Membranous Nephropathy: What Are They and Can They Guide Us?
    10:30 AM - 11:00 AM
    Elion Hoxha, MD
  • Animal Models of Primary Membranous Glomerulopathy
    11:00 AM - 11:30 AM
    Rolf A. Stahl, MD 
  • The Value of a Kidney Biopsy in Membranous Nephropathy
    11:30 AM - 12:00 PM
    Sanjeev Sethi, MD, PhD 
  • Treating Primary Membranous Nephropathy: Whom, When, and How?
    12:00 PM - 12:30 PM
    Fernando C. Fervenza, MD, PhD, FASN