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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Tubular Maladaptive Responses After Injury: New Paradigm in Kidney Fibrosis, Including the Barry M. Brenner, MD, Endowed Lectureship

October 22, 2020 | 10:30 AM - 12:30 PM

Location: Simulive

Session Description

Tubular epithelial cells are the epicenter of kidney injury and often undergo maladaptive responses characterized by cell cycle arrest, metabolic reprogramming, and cell senescence, leading to a secretory phenotype with an increased secretion of profibrotic factors and extracellular vesicles. As such, tubular cells play a central role in initiating fibroblast activation and kidney fibrogenesis. This session discusses the emerging literature on the role and mechanism of tubular maladaptive responses in mediating fibroblast activation and kidney fibrosis after injury.

ASN gratefully acknowledges Monarch Pharmaceuticals for support of the Barry M. Brenner, MD, Endowed Lectureship.

Learning Objective(s)

  • Describe the role of tubular maladaptive responses in the pathogenesis of kidney fibrosis
  • Explain how tubular cell-derived profibrotic factors and exosomes mediate fibroblast activation
  • Discuss the mechanism of tubular cell senescence and its potential therapeutic strategies

Learning Pathway(s)

  • Pathology
  • Chronic Kidney Disease


  • Sandeep K. Mallipattu, MD, FASN
  • Jing Nie


  • Tubular Cell Metabolic Reprogramming in Renal Fibrogenesis: The Barry M. Brenner, MD, Endowed Lectureship
    10:30 AM - 11:00 AM
    Katalin Susztak, MD, PhD
  • Tubular Cell Cycle Arrest and Fibrotic Maladaptive Repair
    11:00 AM - 11:30 AM
    Joseph V. Bonventre, MD, PhD, FASN 
  • Tubular Epithelial-Mesenchymal Communication: Mediators and Mechanism
    11:30 AM - 12:00 PM
    Youhua Liu, PhD, FASN
  • Tubular Cell Senescence and Kidney Fibrosis
    12:00 PM - 12:30 PM
    Peter L.J. de Keizer, PhD