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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Intercellular Communication in the Pathogenesis of CKD

October 25, 2020 | 10:00 AM - 12:00 PM

Location: On-Demand

Session Description

Cell-to-cell communication plays an essential role in kidney homeostasis and disease. Intercellular cross-talk could be mediated by multiple means, including soluble factors and extracellular vesicles such as exosomes. Recent studies reveal a complex network of intercellular communication leading to renal inflammation and kidney fibrosis in the pathogenesis of CKD. This session discusses the emerging literature on intercellular communication between tubular, inflammatory, pericyte/fibroblast, and endothelial cells in the pathogenesis of CKD.

Learning Objective(s)

  • Describe the role of cell-to-cell communication in the pathogenesis of CKD
  • Explain intercellular communication in the pathogenesis of diabetic kidney disease
  • Discuss the role of extracellular vesicles as a vehicle in mediating cell-to-cell communication in CKD

Learning Pathway(s)

  • Pathology
  • Chronic Kidney Disease


  • Allison A. Eddy, MD, FASN
  • Helen Liapis, MD


  • Tubular Cells and Fibroblasts Cross-Talk in the Pathogenesis of Kidney Fibrosis
    10:00 AM - 10:30 AM
    Leslie S. Gewin, MD 
  • Tubular Innate Immunity and Renal Inflammation in CKD
    10:30 AM - 11:00 AM
    Sydney C.W. Tang, MD, MBBS, PhD 
  • Intercellular Communication in the Pathogenesis of Diabetic Kidney Disease
    11:00 AM - 11:30 AM
    John Cijiang He, MD, PhD, FASN
  • Extracellular Vesicles as a Vehicle Mediate Cell-Cell Communication
    11:30 AM - 12:00 PM
    Diana Karpman, MD, PhD