Kidney Week

Basic/Clinical Science Session

Intercellular Communication in the Pathogenesis of CKD

October 25, 2020 | 10:00 AM - 12:00 PM

Location: On-Demand

Session Description

Cell-to-cell communication plays an essential role in kidney homeostasis and disease. Intercellular cross-talk could be mediated by multiple means, including soluble factors and extracellular vesicles such as exosomes. Recent studies reveal a complex network of intercellular communication leading to renal inflammation and kidney fibrosis in the pathogenesis of CKD. This session discusses the emerging literature on intercellular communication between tubular, inflammatory, pericyte/fibroblast, and endothelial cells in the pathogenesis of CKD.

Learning Objective(s)

• Describe the role of cell-to-cell communication in the pathogenesis of CKD
• Explain intercellular communication in the pathogenesis of diabetic kidney disease
• Discuss the role of extracellular vesicles as a vehicle in mediating cell-to-cell communication in CKD

Learning Pathway(s)

• Pathology
• Chronic Kidney Disease

Moderators

• Allison A. Eddy, MD, FASN
• Helen Liapis, MD

Presentations

• Tubular Cells and Fibroblasts Cross-Talk in the Pathogenesis of Kidney Fibrosis
  10:00 AM - 10:30 AM
  Leslie S. Gewin, MD 
  
  

  Leslie S. Gewin, MD

  Dr. Gewin is a physician-scientist at Vanderbilt University Medical Center who studies the basic mechanisms underlying the progression of chronic kidney disease. She is specifically interested in the injured tubules and how growth factors and cell cycle changes either promote repair or progression of tubulointerstitial fibrosis. She has funding from the National Institutes of Health and a Veteran Affairs Merit Award to support her studies that use a combination of genetically modified mice, cell culture techniques, and metabolic studies. Dr. Gewin attends on the general medicine wards and nephrology consult service at the Nashville VA and follows patients in the chronic kidney disease clinic.

Tubular Cells and Fibroblasts Cross-Talk in the Pathogenesis of Kidney Fibrosis

October 25, 2020 | 10:00 AM - 10:30 AM

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• Tubular Innate Immunity and Renal Inflammation in CKD
  10:30 AM - 11:00 AM
  Sydney C.W. Tang, MD, MBBS, PhD 
  
  

  Sydney C.W. Tang, MD, MBBS, PhD

  1. Chair of Renal Medicine and Yu Professor in Nephrology at The University of Hong Kong 2. Research interests: pathogenetic mechanisms of diabetic and proteinuric nephropathies, and the treatment of IgA nephropathy. 3. SCI publications > 250; book chapters: > 30 including one on diabetic kidney disease in Comprehensive Clinical Nephrology 4. Editorships: Editor-in-chief of Nephrology (Carlton), Theme Editor in DKD for NDT and Editorial Boards of Kl, CJASN, American Journal of Nephrology, and Kidney Diseases 5. Societies and Congress Positions: Asian Pacific Society of Nephrology: President-elect KDIGO: Executive Committee ISN: Deputy Chair, CME Advisory Committee ISPD: Publication Committee Japanese Society of Nephrology: International Honorary Member HK Society of Nephrology: Past President

Tubular Innate Immunity and Renal Inflammation in CKD

October 25, 2020 | 10:30 AM - 11:00 AM

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• Intercellular Communication in the Pathogenesis of Diabetic Kidney Disease
  11:00 AM - 11:30 AM
  John Cijiang He, MD, PhD, FASN
  
  John Cijiang He, MD, PhD, FASN

Intercellular Communication in the Pathogenesis of Diabetic Kidney Disease

October 25, 2020 | 11:00 AM - 11:30 AM

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• Extracellular Vesicles as a Vehicle Mediate Cell-Cell Communication
  11:30 AM - 12:00 PM
  Diana Karpman, MD, PhD 
  
  

  Diana Karpman, MD, PhD

  Diana Karpman is professor of pediatric nephrology at Lund University, Sweden. Professor Karpman is a member of the Royal Swedish Academy of Sciences and a Wallenberg Clinical Scholar. She heads the Skåne Center of Excellence in Health. She obtained her MD at Sackler School of Medicine and her PhD at Lund University. She combines clinical duties in pediatric nephrology with research and teaching. Her research focuses on novel molecular mechanisms of, and treatment options for kidney diseases utilizing laboratory models and patient samples. Her scientific projects are related to EHEC infection, atypical hemolytic uremic syndrome, C3 glomerulopathy, thrombotic thrombocytopenic purpura, IgA nephropathy and vasculitis.

Extracellular Vesicles as a Vehicle Mediate Cell-Cell Communication

October 25, 2020 | 11:30 AM - 12:00 PM

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