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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Translational Session

HIF Is Noble and Nobel

October 22, 2020 | 10:30 AM - 12:30 PM

Location: Simulive

Session Description

The 2019 Nobel prize in Physiology or Medicine was awarded to researchers studying oxygen sensing and adaptive responses against hypoxia; i.e., hypoxia-inducible factor (HIF) and the prolyl hydroxylase (PH) pathway. The findings clarified a mechanism of the most basic and important aspect of cell biology and led to the development of new drugs targeting diseases related to abnormal oxygen metabolism, such as anemia in CKD. This session highlights aspects of this research and the resulting drug innovations.

Learning Objective(s)

  • Discuss the HIF-PH pathway
  • Explain how cells sense and adapt to oxygen availability
  • Describe the clinical evidence supporting drugs that target the HIF-PH pathway

Learning Pathway(s)

  • Chronic Kidney Disease
  • Cell and Transport Physiology

Moderators

  • Volker H. Haase, MD, DrMed
  • Prabhleen Singh, MD, MPH

Presentations

  • HIF-Prolyl Hydroxylase Inhibition for Treating Anemia in CKD
    10:30 AM - 11:00 AM
    Kai-Uwe Eckardt, MD 
  • Oxygen Biology in Kidney Diseases
    11:00 AM - 11:30 AM
    Patrick H. Maxwell, DrMed 
  • Hypoxia-Inducible Factor (HIF) and Energy Metabolism
    11:30 AM - 12:00 PM
    Mai Sugahara, MD, PhD
  • HIF and Kidney Cancer
    12:00 PM - 12:30 PM
    Kimryn Rathmell, MD, PhD