Kidney Week

Basic/Clinical Science Session

From Kids to Adults: CKD-MBD Across the Life Course

October 22, 2020 | 02:30 PM - 04:30 PM

Location: Simulive

Session Description

Kidney diseases starting in childhood result in lifelong exposure of the skeleton and vasculature to uremic toxins, leading to an accelerated aging phenotype characterized by abnormal growth, lack of ascertainment of peak bone mass, increased risk of fractures, and propensity for vascular calcifications. This session reviews the epidemiology of lifelong CKD on bone and vascular clinical outcomes and putative mechanisms by which CKD accelerates skeletal and vascular aging in children and young adults.

Learning Objective(s)

• Describe the effect of lifelong exposure of CKD on bone and vessels
• Summarize the mechanisms of an accelerated aging phenotype in pediatric CKD-MBD
• Explain the differences in levels of fibroblast growth factor 23 between children and adults

Learning Pathway(s)

• Bone and Mineral Metabolism
• Development and Pediatrics

Moderators

• Dorey A. Glenn, MD, MPH
• Isidro B. Salusky, MD, FASN

Presentations

• The Impact of Lifelong CKD on the Skeleton and Vasculature
  02:30 PM - 03:00 PM
  Mary B. Leonard, MD, MS
  

  Mary B. Leonard, MD, MS

The Impact of Lifelong CKD on the Skeleton and Vasculature

October 22, 2020 | 02:30 PM - 03:00 PM

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• Glomerular Disease: Its Impact on the Skeleton and Vitamin D Throughout the Life Course
  03:00 PM - 03:30 PM
  Michelle Denburg, MD
  

  Michelle Denburg, MD

Glomerular Disease: Its Impact on the Skeleton and Vitamin D Throughout the Life Course

October 22, 2020 | 03:00 PM - 03:30 PM

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• The Effects of Fibroblast Growth Factor 23 During Growth and Development
  03:30 PM - 04:00 PM
  Farzana Perwad, MD
  

  Farzana Perwad, MD

The Effects of Fibroblast Growth Factor 23 During Growth and Development

October 22, 2020 | 03:30 PM - 04:00 PM

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• Old Vessels in Young People: Vascular Calcifications in Kids
  04:00 PM - 04:30 PM
  Rukshana Shroff, MD, PhD 
  
  

  Rukshana Shroff, MD, PhD

  Rukshana Shroff is a Consultant in Paediatric Nephrology at Great Ormond Street Hospital for Children, London, and Associate Professor at University College London, UK. Her main research focuses on cardiovascular disease in childhood chronic kidney disease, where she is involved in clinical research studies, clinical trials and laboratory work. Dr Shroff is the Principal Investigator on multicentre research projects comparing long-term outcomes of conventional haemodialysis and haemodiafiltration in children, vitamin D and bone and cardiovascular outcomes. She holds a prestigious senior fellowship from the National Institute for Health Research (NIHR) to develop novel methods of estimating calcium balance. Dr Shroff is co-editor for the 8th edition of Pediatric Nephrology, the definitive textbook in our field. She was elected to serve as a member of the KDIGO Kidney Disease: Improving Global Outcomes (KDIGO) Executive Committee and the KDIGO CKD-MBD Guideline Working Group, as well as serving on two guideline committees for the National Institute for Health and Care Excellence (NICE) and the council of the European Society for Paediatric Nephrology. Currently an Associate Editor for Pediatric Nephrology and serving on the editorial board of the Clinical Journal of the American Society of Nephrology and Peritoneal Dialysis International, Dr Shroff has published more than 200 original articles, reviews and editorials in peer-reviewed journals. She has contributed to the scientific committee of several international meetings.

Old Vessels in Young People: Vascular Calcifications in Kids

October 22, 2020 | 04:00 PM - 04:30 PM

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