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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

From Kids to Adults: CKD-MBD Across the Life Course

October 22, 2020 | 02:30 PM - 04:30 PM

Location: Simulive

Session Description

Kidney diseases starting in childhood result in lifelong exposure of the skeleton and vasculature to uremic toxins, leading to an accelerated aging phenotype characterized by abnormal growth, lack of ascertainment of peak bone mass, increased risk of fractures, and propensity for vascular calcifications. This session reviews the epidemiology of lifelong CKD on bone and vascular clinical outcomes and putative mechanisms by which CKD accelerates skeletal and vascular aging in children and young adults.

Learning Objective(s)

  • Describe the effect of lifelong exposure of CKD on bone and vessels
  • Summarize the mechanisms of an accelerated aging phenotype in pediatric CKD-MBD
  • Explain the differences in levels of fibroblast growth factor 23 between children and adults

Learning Pathway(s)

  • Bone and Mineral Metabolism
  • Development and Pediatrics


  • Dorey A. Glenn, MD, MPH
  • Isidro B. Salusky, MD, FASN


  • The Impact of Lifelong CKD on the Skeleton and Vasculature
    02:30 PM - 03:00 PM
    Mary B. Leonard, MD, MS
  • Glomerular Disease: Its Impact on the Skeleton and Vitamin D Throughout the Life Course
    03:00 PM - 03:30 PM
    Michelle Denburg, MD
  • The Effects of Fibroblast Growth Factor 23 During Growth and Development
    03:30 PM - 04:00 PM
    Farzana Perwad, MD
  • Old Vessels in Young People: Vascular Calcifications in Kids
    04:00 PM - 04:30 PM
    Rukshana Shroff, MD, PhD