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Clinical Practice Session
Podocytopathies: How Far Does the Renal Biopsy Take Us?
October 23, 2020 | 10:00 AM - 12:00 PM
Location: On-Demand
Session Description
Podocyte dysfunction is a fundamental aspect of numerous types of glomerular diseases. This session seeks to enhance our understanding of renal diseases involving podocytes in native and allograft kidneys and highlights new insights into mechanisms of podocyte dysfunction, with an emphasis on correlating these findings with changes found in renal biopsies.
Learning Objective(s)
- Assess new insights into the pathophysiology of minimal change disease
- Describe various molecular biomarkers associated with FSGS
- Evaluate new data regarding immune-mediated pathogenesis of podocyte dysfunction in lupus
- Discuss the importance of donor-related factors in glomerular diseases of the renal allograft
Learning Pathway(s)
- Pathology
- Glomerular Diseases
Moderators
Presentations
- Minimal Change Disease: New Insights for an Old Disease?
10:00 AM - 10:30 AM
- Astrid Weins, MD, PhD, FASN
Astrid Weins, MD, PhD, FASN
I am a Renal Pathologist at Brigham and Women's Hospital in Boston, MA, with 10 years of experience in evaluating kidney biopsies, and an Assistant Professor of Pathology at Harvard Medical School with an active research program. My laboratory focuses on translational and collaborative research investigating the causes and progression of proteinuric kidney disease, specifically of primary podocytopathies (Minimal Change Disease and Focal Segmental Glomerulosclerosis (FSGS)). As a cell biologist with extensive experience in evaluating in vitro and in vivo model systems of podocyte injury, I greatly enjoy discussing the complex morphological and pathobiological aspects of this poorly understood group of diseases.
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- Molecular Biomarkers in FSGS
10:30 AM - 11:00 AM
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- Immune-Mediated Podocyte Injury in Lupus Nephritis
11:00 AM - 11:30 AM
- George C. Tsokos, MD
George C. Tsokos, MD
George C. Tsokos, MD, is a Professor of Medicine at Harvard Medical School and Chief of the Rheumatology and Clinical Immunology Division at Beth Israel Deaconess Medical Center in Boston. Dr. Tsokos’ laboratory has opened and led the field of molecular abnormalities on immune cells in patients with systemic lupus erythematosus and identified previously unknown pathways which have served as the basis for novel treatments which are currently in various phases of development. More recently he has launched studies to decipher the interaction between immune and kidney resident cells and identify local processes that enable renal injury. He has served various leadership positions including President of the Clinical Immunology Society, the Board of Directors of the American College of Rheumatology and the Lupus Foundation of America and member or chair of multiple federal study sections and editor or the editorial boards of top scientific journals. He holds a MERIT Award from the National Institutes of Health and has received several prestigious awards including the Kirkland, Howley, Evelyn Hess awards and the Distinguished Basic Investigator Award from the American College of Rheumatology, the Lupus Insight Award, the Carol Nachman International Prize in Rheumatology and the Marian Ropes Physician Achievement Award. He is a Master of the American College of Physicians and Rheumatology.
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- Podocytopathies in the Renal Allograft: Does the Donor Matter?
11:30 AM - 12:00 PM
- Ibrahim Batal, MD
Ibrahim Batal, MD
I am a Renal Pathologist and an Associate Professor of Pathology and Cell Biology at Columbia University in New York. I received my training in Transplant Pathology at the University of Pittsburgh under the mentorship of Drs. Demetris and Randhawa and in Renal Pathology at the Brigham and Woman’s Hospital/Harvard Medical School under the mentorship of Dr. Rennke. My research focuses on (1) Assessing the pathogenesis of glomerular diseases in the kidney allograft, which offers unique environment to dissect culprit factors from recipients and donors (2) Studying the role of kidney dendritic cells in shaping renal allograft inflammation to provide a rationale for targeted therapy and ultimately improve patients’ outcome.
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