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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Clinical Practice Session

Disease Mechanisms and Treatment Concepts in IgA Nephropathy

October 22, 2020 | 02:30 PM - 04:30 PM

Location: Simulive

Session Description

IgA nephropathy is the most common glomerulonephritis worldwide. This session reviews recent advances in our understanding of genetic factors and the contribution of aberrant IgA1 O-linked glycosylation to IgA nephropathy. Treatment approaches ranging from supportive measures to steroids and immunosuppressive drugs are discussed based on a case vignette and updated KDIGO guidelines. Clinical and histological disease features that may assist in predicting patient outcome are also analyzed.

Support is provided by an educational grant from Chinook Therapeutics, Inc.

Learning Objective(s)

  • Describe recent advances in understanding the pathogenesis of IgA nephropathy
  • Highlight the pros and cons of supportive versus immune-modulating treatments in IgA nephropathy
  • Discuss the rationale for the updated KDIGO guidelines
  • Identify and evaluate risk prediction tools in the clinical management of patients with IgA nephropathy

Learning Pathway(s)

  • Glomerular Diseases
  • Pathology


  • Brad H. Rovin, MD, FASN
  • Shikha Wadhwani, MD, MS


  • Recent Advances in the Pathogenesis of IgA Nephropathy
    02:30 PM - 03:00 PM
    Pietro A. Canetta, MD, MS
  • At Least Steroids Are in Order for This IgA Nephropathy Patient
    03:00 PM - 03:30 PM
    Heather N. Reich, MD, PhD
  • Supportive Measures Will Do for This IgA Nephropathy Patient
    03:30 PM - 04:00 PM
    Jürgen Floege, MD
  • One and One Is Three: Predicting Patient Outcome in IgA Nephropathy
    04:00 PM - 04:30 PM
    Sean Barbour, MD