Thrombotic Microangiopathy in 2020: Complement at the Forefront
October 22, 2020 | 10:00 AM - 12:00 PM
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Clinical Practice Session
Thrombotic Microangiopathy in 2020: Complement at the Forefront
October 22, 2020 | 10:00 AM - 12:00 PM
Location: On-Demand
Session Description
There have been major advancements in understanding of thrombotic microangiopathy (TMA). Complement has been shown to play a major role in TMA. Genetic and functional assays of the complement pathway are keys to classification of TMA. Newer methods such as mass spectrometry are being used to determine the complement burden and pathways involved in TMA. Both existing and new anticomplement drugs will play a major role in the management of TMA. This session highlights the clinicopathologic findings, complement pathways, new methodologies, and management of TMA in the current era.
Learning Objective(s)
- Summarize recent advances in the hereditability and therapeutics of complement disorders
- Discuss the diagnosis and underlying biology of TMA
- Explain the role of functional assays and genetics in the clinical management of TMA
Learning Pathway(s)
- Glomerular Diseases
- Pathology
Moderators
- Anuja Java, MD
- Cynthia C. Nast, MD, FASN
Presentations
- Thrombotic Microangiopathies: New Methodologies to Unravel Underlying Mechanisms
10:00 AM - 10:30 AM
Lilian MP Palma, DrMed
Lilian MP Palma, DrMed
Pediatric Nephrologist - State University of Campinas (Brazil)
Member of the TMA&aHUS Brazilian Study Group
Thrombotic Microangiopathies: New Methodologies to Unravel Underlying Mechanisms
October 22, 2020 | 10:00 AM - 10:30 AM
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- Hereditability and Dysregulation of the Complement System: Functional Assays and Genetic Testing
10:30 AM - 11:00 AM
Marina Noris, PhD
Marina Noris, PhD
Qualifications:
1986: degree in Pharmaceutical chemistry and technology (University of Rome “La Sapienza”)
2006: PhD in Genetics (University of Maastricht )
Current appointment: Head of the Laboratory of Immunology and Genetic of Rare Diseases, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Ranica, Bergamo, Italy
2020-: Member of the of the Editorial Board of JASN
2020-: Member of the Editorial Board of Kidney International
2016-: Member of the Research Club “Top Italian Women Scientists” promoted by ONDA.
H-index: 74
Main work and research experience
Marina Noris has an in-depth expertise in rare genetic renal diseases particularly in rare complement related kidney diseases. In this field she contributed to discover the genetic causes of aHUS, describing mutations in genes encoding complement regulatory proteins, factor H, membrane cofactor protein and thrombomodulin and their functional consequences. Her discoveries have been described in several publications in high impact journals, including the Lancet, Blood, the Journal of the American Society of Nephrology and the New England Journal of Medicine. Her research also clarified that the specific genetic defect has a great impact on the clinical course of this disease and on the risk of disease recurrence after kidney transplantation and contributed to the achievement of a specific cure with the anti-C5 antibody eculizumab.
Her group also discovered the genetic cause of very rare renal disease, the glomerulopathy with fibronectin deposits and a new genetic form of childhood onset familial FSGS associated with mutation in the myosin 1E gene. MN has been invited to hold lectures at a number of National and International congresses and is author and co-author of more than 210 scientific articles, reviews and monographs.
Hereditability and Dysregulation of the Complement System: Functional Assays and Genetic Testing
October 22, 2020 | 10:30 AM - 11:00 AM
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- Practical Approach to Managing Thrombotic Microangiopathies in 2020
11:00 AM - 11:30 AM
John Sperati, MD
Practical Approach to Managing Thrombotic Microangiopathies in 2020
October 22, 2020 | 11:00 AM - 11:30 AM
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- Agents in the Pipeline for Treating Complement Disorders
11:30 AM - 12:00 PM
Joshua M. Thurman, MD
Agents in the Pipeline for Treating Complement Disorders
October 22, 2020 | 11:30 AM - 12:00 PM
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