Kidney Week

Clinical Practice Session

Thrombotic Microangiopathy in 2020: Complement at the Forefront

October 22, 2020 | 10:00 AM - 12:00 PM

Location: On-Demand

Session Description

There have been major advancements in understanding of thrombotic microangiopathy (TMA). Complement has been shown to play a major role in TMA. Genetic and functional assays of the complement pathway are keys to classification of TMA. Newer methods such as mass spectrometry are being used to determine the complement burden and pathways involved in TMA. Both existing and new anticomplement drugs will play a major role in the management of TMA. This session highlights the clinicopathologic findings, complement pathways, new methodologies, and management of TMA in the current era.

Learning Objective(s)

• Summarize recent advances in the hereditability and therapeutics of complement disorders
• Discuss the diagnosis and underlying biology of TMA
• Explain the role of functional assays and genetics in the clinical management of TMA

Learning Pathway(s)

• Glomerular Diseases
• Pathology

Moderators

• Anuja Java, MD
• Cynthia C. Nast, MD, FASN

Presentations

• Thrombotic Microangiopathies: New Methodologies to Unravel Underlying Mechanisms
  10:00 AM - 10:30 AM
  Lilian MP Palma, DrMed 
  
  

  Lilian MP Palma, DrMed

  Pediatric Nephrologist - State University of Campinas (Brazil) Member of the TMA&aHUS Brazilian Study Group

Thrombotic Microangiopathies: New Methodologies to Unravel Underlying Mechanisms

October 22, 2020 | 10:00 AM - 10:30 AM

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• Hereditability and Dysregulation of the Complement System: Functional Assays and Genetic Testing
  10:30 AM - 11:00 AM
  Marina Noris, PhD 
  
  

  Marina Noris, PhD

  Qualifications: 1986: degree in Pharmaceutical chemistry and technology (University of Rome “La Sapienza”) 2006: PhD in Genetics (University of Maastricht ) Current appointment: Head of the Laboratory of Immunology and Genetic of Rare Diseases, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Ranica, Bergamo, Italy 2020-: Member of the of the Editorial Board of JASN 2020-: Member of the Editorial Board of Kidney International 2016-: Member of the Research Club “Top Italian Women Scientists” promoted by ONDA. H-index: 74 Main work and research experience Marina Noris has an in-depth expertise in rare genetic renal diseases particularly in rare complement related kidney diseases. In this field she contributed to discover the genetic causes of aHUS, describing mutations in genes encoding complement regulatory proteins, factor H, membrane cofactor protein and thrombomodulin and their functional consequences. Her discoveries have been described in several publications in high impact journals, including the Lancet, Blood, the Journal of the American Society of Nephrology and the New England Journal of Medicine. Her research also clarified that the specific genetic defect has a great impact on the clinical course of this disease and on the risk of disease recurrence after kidney transplantation and contributed to the achievement of a specific cure with the anti-C5 antibody eculizumab. Her group also discovered the genetic cause of very rare renal disease, the glomerulopathy with fibronectin deposits and a new genetic form of childhood onset familial FSGS associated with mutation in the myosin 1E gene. MN has been invited to hold lectures at a number of National and International congresses and is author and co-author of more than 210 scientific articles, reviews and monographs.

Hereditability and Dysregulation of the Complement System: Functional Assays and Genetic Testing

October 22, 2020 | 10:30 AM - 11:00 AM

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• Practical Approach to Managing Thrombotic Microangiopathies in 2020
  11:00 AM - 11:30 AM
  John Sperati, MD 
  
  

  John Sperati, MD

Practical Approach to Managing Thrombotic Microangiopathies in 2020

October 22, 2020 | 11:00 AM - 11:30 AM

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• Agents in the Pipeline for Treating Complement Disorders
  11:30 AM - 12:00 PM
  Joshua M. Thurman, MD
  

  Joshua M. Thurman, MD

Agents in the Pipeline for Treating Complement Disorders

October 22, 2020 | 11:30 AM - 12:00 PM

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