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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Clinical Practice Session

Thrombotic Microangiopathy in 2020: Complement at the Forefront

October 22, 2020 | 10:00 AM - 12:00 PM

Location: On-Demand

Session Description

There have been major advancements in understanding of thrombotic microangiopathy (TMA). Complement has been shown to play a major role in TMA. Genetic and functional assays of the complement pathway are keys to classification of TMA. Newer methods such as mass spectrometry are being used to determine the complement burden and pathways involved in TMA. Both existing and new anticomplement drugs will play a major role in the management of TMA. This session highlights the clinicopathologic findings, complement pathways, new methodologies, and management of TMA in the current era.

Learning Objective(s)

  • Summarize recent advances in the hereditability and therapeutics of complement disorders
  • Discuss the diagnosis and underlying biology of TMA
  • Explain the role of functional assays and genetics in the clinical management of TMA

Learning Pathway(s)

  • Glomerular Diseases
  • Pathology


  • Anuja Java, MD
  • Cynthia C. Nast, MD, FASN


  • Thrombotic Microangiopathies: New Methodologies to Unravel Underlying Mechanisms
    10:00 AM - 10:30 AM
    Lilian MP Palma, DrMed 
  • Hereditability and Dysregulation of the Complement System: Functional Assays and Genetic Testing
    10:30 AM - 11:00 AM
    Marina Noris, PhD 
  • Practical Approach to Managing Thrombotic Microangiopathies in 2020
    11:00 AM - 11:30 AM
    John Sperati, MD 
  • Agents in the Pipeline for Treating Complement Disorders
    11:30 AM - 12:00 PM
    Joshua M. Thurman, MD