Targeting Metabolism for Immunomodulation
October 23, 2020 | 02:30 PM - 04:30 PM
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Basic/Clinical Science Session
Targeting Metabolism for Immunomodulation
October 23, 2020 | 02:30 PM - 04:30 PM
Location: Simulive
Session Description
This session describes the metabolic pathways used by immune cells and potential manipulations of these pathways that can modify immune function to alter the allograft response.
Learning Objective(s)
- Describe the pathways used for cellular metabolism
- Explain how metabolic alterations can alter immune cell differentiation
- Describe studies that modify immune cell metabolism to alter immune responses
Learning Pathway(s)
- Transplantation/Immunology
- Diabetes and Metabolism
Moderators
- Ulf H. Beier, MD, DrMed
- Xun-Rong Luo, MD, PhD
Presentations
- Mitochondrial Metabolism in T Cell Differentiation
02:30 PM - 03:00 PM
Will Bailis, PhD
Will Bailis, PhD
Dr. Will Bailis is an Assistant Professor in the Department of Pathology and Laboratory Medicine at the University of Pennsylvania and the Children’s Hospital of Philadelphia. He received his PhD in immunology from the University of Pennsylvania, where he studied the role of Notch signaling in helper T cell differentiation in laboratory of Dr. Warren Pear. He then joined the laboratory of Dr. Richard Flavell at Yale University for his postdoctoral fellowship, where he studied how cellular metabolism controls immune cell functional programming using CRISPR screening. Now at the Children’s Hospital of Philadelphia and the University of Pennsylvania, the Bailis laboratory aims to understand how the spatial partitioning of metabolism (between organelles in cells, amongst cells in tissues, and across the organ systems of the body) controls development and function in the immune system.
Mitochondrial Metabolism in T Cell Differentiation
October 23, 2020 | 02:30 PM - 03:00 PM
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- Metabolic Reprogramming of Macrophages in Autoimmunity
03:00 PM - 03:30 PM
Cornelia Weyand, MD, PhD
Metabolic Reprogramming of Macrophages in Autoimmunity
October 23, 2020 | 03:00 PM - 03:30 PM
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- Targeting CD44 to Modulate T Cell Metabolism
03:30 PM - 04:00 PM
Paul L. Bollyky, MD, PhD
Paul L. Bollyky, MD, PhD
Paul Bollyky, MD, PhD is an Immunologist at Stanford University. He completed his PhD at Oxford, and attended Harvard for Medical School. He completed his Internal Medicine training at Brigham and Women's Hospital in Boston and his Infectious Diseases training at the University of Washington. Paul has been a faculty member at Stanford since 2013 and is currently an Associate Professor. Paul's lab studies the innate immune response to injured and infected tissues. In particular, he studies how inflamed extracellular matrix in the kidney and other sites influences local immune responses and how these pathways can be targeted to prevent chronic inflammation and fibrosis.
Targeting CD44 to Modulate T Cell Metabolism
October 23, 2020 | 03:30 PM - 04:00 PM
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- Immunosuppression Through Targeting Glutamine Metabolism
04:00 PM - 04:30 PM
Jonathan D. Powell, MD, PhD
Jonathan D. Powell, MD, PhD
Immunosuppression Through Targeting Glutamine Metabolism
October 23, 2020 | 04:00 PM - 04:30 PM
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