Kidney Week

Advances in Research Conference: Single-Cell Biology

Advances in Research Conference: Single-Cell Biology - III. Organoid Modeling (On-Demand)

October 14, 2020 | 12:00 PM - 01:30 PM

Location: On-Demand

Session Description

Early Program "Advances in Research Conference: Single-Cell Biology"

Support is provided by an educational grant from Chinook Therapeutics, Inc.

Presentations

• Lineage and Cell State Reconstruction Using Single Cell Technologies
  12:00 PM - 12:30 PM
  Sahand Hormoz, PhD 
  
  

  Sahand Hormoz, PhD

  Dr. Hormoz is an Assistant Professor with the Department Systems Biology at Harvard Medical School and the Department of Data Sciences at the Dana-Farber Cancer Institute. His lab uses theory and experiments to understand the dynamics of cell state transitions in development and disease. Dr. Hormoz obtain his PhD from Harvard University and completed his postdoctoral training at UCSB and Caltech.

Lineage and Cell State Reconstruction Using Single Cell Technologies

October 14, 2020 | 12:00 PM - 12:30 PM

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• Dissecting Kidney Organoids One Cell at a Time: Cell Identity and Fate
  12:30 PM - 01:00 PM
  Melissa H. Little, PhD 
  
  

  Melissa H. Little, PhD

  Professor Melissa Little, BSc PhD GAICD, FAAHMS, FAA is the Theme Director of Cell Biology at the Murdoch Children’s Research Institute in Melbourne, Australia. She is internationally recognised for her work on the systems biology of kidney development. For more than two decades, her work has investigated the molecular and cellular basis of kidney development and disease. This fundamental research has underpinned her pioneering studies into potential regenerative therapies for kidney disease. As a result, her team have developed approaches for directing the differentiation of human pluripotent stem cells to human kidney organoids. Her group are applying this knowledge to disease modelling, drug screening, cell therapy and tissue engineering. Professor Little is an NHMRC Senior Principal Research Fellow at MCRI, Program Leader of Stem Cells Australia and Professor, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne. Melissa is Vice-President of the Board of ISSCR, and immediate past President of ASSCR. A Fellow of the Australian Academy of Science and the Australian Academy of Health and Medical Sciences, Professor Little’s work has been recognised by many awards, including the GlaxoSmithKline Award for Research Excellence (2005), AAS Gottschalk Medal in Medical Sciences (2004), Eisenhower Fellowship (2006), ANZSCDB Presidents Medal (2015), Boerhaave Professorship, Leiden University (2015), UNSW Eureka Prize (2016) and the NHMRC Elizabeth Blackburn Fellowship Biomedical (2018), Honorary Doctorate, Leiden University (2019), the prestigious Alfred Newton Richards Award (2019), and the Julian Wells Medal (2020).

Dissecting Kidney Organoids One Cell at a Time: Cell Identity and Fate

October 14, 2020 | 12:30 PM - 01:00 PM

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• Modeling Cystic Kidney Disease Using Kidney Organoids
  01:00 PM - 01:30 PM
  Benjamin S. Freedman, PhD 
  
  

  Benjamin S. Freedman, PhD

  Dr. Benjamin “Beno” Freedman, Ph.D. is an Assistant Professor of Medicine at the University of Washington, in Seattle. He has been continuously studying the cell biology of vertebrate stem cells for fifteen years. Hallmarks of his career include 1) the application of stem cells for studying disease and regeneration, 2) quantitative comparison of gene mutants, 3) functional assays providing stoichiometric insight into protein dynamics and activity, and 4) reconstitution of complex physiological phenomena in defined component systems in vitro. Dr. Freedman studied mammalian epimorphic regeneration after injury as an undergraduate at the University of Pennsylvania. Subsequently, he investigated cytoplasmic remodeling of germline nuclear DNA as a doctoral student at the University of California at Berkeley. These experiences provided Dr. Freedman with his fundamental training in the cell biology of stem cells. Several members of Dr. Freedman’s family suffer from kidney disease, prompting him to investigate the potential of human pluripotent stem cells (hPSC) for this fascinating organ. At Harvard Medical School, he led a multi-institute collaboration to generate and characterize hPSC from polycystic kidney disease (PKD) patients. This led to the identification of the first hPSC phenotype relevant to kidney disease and a possible therapeutic approach. He subsequently developed protocols directing differentiation of hPSC into kidney progenitor cells and kidney organoids that functionally model morphogenesis, physiology, and injury. Combining this with CRISPR/Cas9 genome-editing, Dr. Freedman has established kidney organoid models of genetic diseases, including PKD and glomerulosclerosis. Currently, Dr. Freedman’s group is combining hPSC, bioengineering, and genome editing to model disease and, eventually, regenerative therapy. His long-term career goals are to make fundamental scientific discoveries, apply these to benefit society, and help educate the next generation of scientists.

Modeling Cystic Kidney Disease Using Kidney Organoids

October 14, 2020 | 01:00 PM - 01:30 PM

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