In-Depth Look at Transplantation: Basic and Translational
October 23, 2020 | 05:00 PM - 07:00 PM
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Oral Abstract Session
In-Depth Look at Transplantation: Basic and Translational
October 23, 2020 | 05:00 PM - 07:00 PM
Location: Simulive
Session Description
Oral Abstract Session
Learning Pathway(s)
- Transplantation/Immunology
Moderators
- Jamil R. Azzi, MD
- Paolo Cravedi, MD, PhD
Presentations
- Harnessing Expressed Single-Nucleotide Variation and Single-Cell RNA Sequencing to Define Immune Cell Chimerism in the Rejecting Kidney Transplant
05:00 PM - 07:00 PM
Andrew F. Malone, MBChB, MD, FASN
Andrew F. Malone, MBChB, MD, FASN
Harnessing Expressed Single-Nucleotide Variation and Single-Cell RNA Sequencing to Define Immune Cell Chimerism in the Rejecting Kidney Transplant
October 23, 2020 | 05:00 PM - 07:00 PM
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- Proteomics Reveals Extracellular Matrix Injury in the Glomeruli and Tubulointerstitium of Kidney Allografts with Early Antibody-Mediated Rejection
05:00 PM - 07:00 PM
Sergi Clotet Freixas, PhD
Sergi Clotet Freixas, PhD
Dr. Sergi Clotet-Freixas completed his Bachelor of Biotechnology at the Universitat Autònoma of Barcelona (2010), and a Master’s degree in Biomedical Research at the University of Barcelona (2011). In 2012, he embarked on a PhD in basic science at the Hospital del Mar in Barcelona. The aim of his PhD was to explore the effect of sex on experimental diabetic kidney disease (DKD) and the renin-angiotensin system. Dr. Clotet-Freixas uncovered a critical role of androgens and a sex-specific role of angiotensin-converting enzyme 2 in DKD progression. These observations may shed new light on sex-specific approaches to the treatment of DKD. As a PhD student, Dr. Clotet-Freixas also discovered a novel link between male sex hormones and impaired energy metabolism in the diabetic kidney, which may help to understand the more rapid kidney disease progression associated with male sex.
Since the completion of his PhD, Dr. Clotet-Freixas has been working as a post-doctoral fellow in the laboratory of Dr. Ana Konvalinka at the University Health Network in Toronto. He is continuing to study the role of cell sex and sex hormones on the metabolic function of renal tubular cells. Dr. Clotet-Freixas is also expanding his expertise in other kidney-related disease settings. His recent proteomics findings uncovered a compartment-specific remodeling of the extracellular matrix (ECM) in early antibody-mediated rejection (AMR) after kidney transplantation. These novel observations could help explain the development of basement membrane injury that often occurs in AMR at more advanced stages. Dr.Clotet-Freixas is currently exploring the link between key antibodies and cytokines involved in AMR and cell-specific mechanisms of ECM remodeling in kidney cells. Early targeting of ECM remodeling may be the key to prevent the progression of AMR and other kidney diseases in which basement membrane injury plays a central role.
Proteomics Reveals Extracellular Matrix Injury in the Glomeruli and Tubulointerstitium of Kidney Allografts with Early Antibody-Mediated Rejection
October 23, 2020 | 05:00 PM - 07:00 PM
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- Interim Update of the MDR-101-MLK Phase 3 Trial: MERCURY Study
05:00 PM - 07:00 PM
Dixon Kaufman, MD, PhD
Dixon Kaufman, MD, PhD
Dixon B. Kaufman, MD, PhD, FACS, received his medical, general surgical and transplant surgery training at the University of Minnesota (1979-1992). He was a faculty member at the Feinberg School of Medicine of Northwestern University (1992- 2011), rising to the rank of tenured Professor as the endowed Fowler McCormick Professor of Surgery. He is currently the Ray D. Owen Tenured Professor and Medical Director of the UW Health Transplant Center of the University of Wisconsin Hospitals and Clinic of the University of Wisconsin.
He continues his active practice of transplantation surgery with a clinical focus on kidney and pancreas transplantation.
He is actively involved in transplantation research. His basic research efforts have focused on the immunobiology of islet transplantation, and most recently on kidney transplant immunological tolerance supported by the National Institutes of Health (NIH) Non-human Primate Consortium Study Group. His clinical research activities include participation in Clinical Islet Transplant (CIT) consortium, and current studies in kidney transplant tolerance induction. He is also committed to training the next generation of transplant researchers as PI of an NIH T32 training grant awarded to UW. Dr. Kaufman has received over 20 years of research funding awarded by the NIH.
His curriculum vitae lists over 200 manuscripts and book chapters. Dr. Kaufman is an associate editor for the American Journal of Transplantation and Transplantation Journal. He is a frequently invited speaker at national and international transplant programs, symposia and visiting professorships. He has received numerous awards and honors including the Baxter Faculty Scholarship Award, the American Society of Transplant Surgeons Research Career Development Award, and is a member of Alpha Omega Alpha (AOA) – National Medical Honor Society.
Dr. Kaufman has held national leadership positions in many facets of the transplant field. He has been active with the United Network for Organ Sharing (UNOS), recently completing service as a member of the Executive Board. Dr. Kaufman recently served as President of the American Society of Transplant Surgeons (2018-19) and is currently Past President.
Interim Update of the MDR-101-MLK Phase 3 Trial: MERCURY Study
October 23, 2020 | 05:00 PM - 07:00 PM
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- Single-Cell Profiling of Peripheral Blood Mononuclear Cell Identifies Immune Populations Associated with High Risk of Early Acute Rejection
05:00 PM - 07:00 PM
Weijia Zhang
Single-Cell Profiling of Peripheral Blood Mononuclear Cell Identifies Immune Populations Associated with High Risk of Early Acute Rejection
October 23, 2020 | 05:00 PM - 07:00 PM
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- Single-Cell RNA-Sequencing Analysis of Kidney Transplant Biopsies Demonstrates a Proinflammatory Role for Renal Tubular Cells in Rejection
05:00 PM - 07:00 PM
Andrew F. Malone, MBChB, MD, FASN
Andrew F. Malone, MBChB, MD, FASN
Single-Cell RNA-Sequencing Analysis of Kidney Transplant Biopsies Demonstrates a Proinflammatory Role for Renal Tubular Cells in Rejection
October 23, 2020 | 05:00 PM - 07:00 PM
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- Modified Immune Cell Infusion in Kidney Transplantation
05:00 PM - 07:00 PM
Christian Morath, MD
Modified Immune Cell Infusion in Kidney Transplantation
October 23, 2020 | 05:00 PM - 07:00 PM
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- Normothermic Ex Vivo Kidney Perfusion in a Porcine Auto-Transplantation Model Preserves the Expression of Key Mitochondrial Proteins: An Unbiased Proteomics Analysis
05:00 PM - 07:00 PM
Caitriona M. McEvoy, MBChB, PhD
Caitriona M. McEvoy, MBChB, PhD
Normothermic Ex Vivo Kidney Perfusion in a Porcine Auto-Transplantation Model Preserves the Expression of Key Mitochondrial Proteins: An Unbiased Proteomics Analysis
October 23, 2020 | 05:00 PM - 07:00 PM
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- Cyclosporine-Induced Endothelial Injury and Complement Activation Is Caused by Impaired Complement Factor H Binding to the Glycocalyx
05:00 PM - 07:00 PM
Chia Wei Teoh, MBChB
Chia Wei Teoh, MBChB
Dr Chia Wei Teoh is a paediatric nephrologist at The Hospital for Sick Children and Assistant Professor in the Department of Paediatrics at the University of Toronto. His clinical and research interests focuses on complement-mediated injury in transplantation and improving long-term outcomes in paediatric kidney transplantation.
Cyclosporine-Induced Endothelial Injury and Complement Activation Is Caused by Impaired Complement Factor H Binding to the Glycocalyx
October 23, 2020 | 05:00 PM - 07:00 PM
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- Epigenome-Wide Microarray Analysis of Pre- and Post-Transplant Methylation Profiles in Kidney Transplant Recipients
05:00 PM - 07:00 PM
Katie Kerr
Katie Kerr
Katie Kerr is a final year PhD student researching the effectiveness of innovative omic technologies for disease research, within the Molecular Epidemiology and Public Health team at Queen’s University Belfast. Throughout her PhD, Katie has developed a particular interest in nephrology and to this end she has published a systematic review highlighting DNA methylation for inherited renal diseases, in addition to a scoping review and protocol for conducting multi-omic disease research. She has also conducted integrated epigenomic and transcriptomic analysis on kidney transplant recipients to identify multi-omic markers of chronic kidney disease, which was presented at the American Society of Human Genetics international conference in Houston (USA) in 2019. Currently, Katie is working with the 100,000 Genomes Project in Northern Ireland to conduct omic analysis to improve diagnostic rates of rare renal phenotypes. Her novel work on the epigenome wide analysis of pre- and post-transplant methylation profiles hopes to highlight epigenetic changes resulting from kidney transplantation to ultimately improve patient outcomes.
Epigenome-Wide Microarray Analysis of Pre- and Post-Transplant Methylation Profiles in Kidney Transplant Recipients
October 23, 2020 | 05:00 PM - 07:00 PM
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- Impact of Caspase-1 Deletion on Apoptosis and AKI in a Murine Transplant Model
05:00 PM - 07:00 PM
Swati Jain, PhD
Impact of Caspase-1 Deletion on Apoptosis and AKI in a Murine Transplant Model
October 23, 2020 | 05:00 PM - 07:00 PM
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