Molecular Insights in Ion, Acid, and Water Handling
October 22, 2020 | 05:00 PM - 07:00 PM
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Oral Abstract Session
Molecular Insights in Ion, Acid, and Water Handling
October 22, 2020 | 05:00 PM - 07:00 PM
Location: Simulive
Session Description
Oral Abstract Session
Learning Pathway(s)
- Cell and Transport Physiology
Moderators
- Mark A. Knepper, MD, PhD
- Nirupama Ramkumar, MD, MPH, FASN
Presentations
- Primary Cilia and the Glycocalyx Are Flow Sensors for Nitric Oxide Production by Thick Ascending Limbs
05:00 PM - 07:00 PM
Jeffrey L. Garvin, PhD
Primary Cilia and the Glycocalyx Are Flow Sensors for Nitric Oxide Production by Thick Ascending Limbs
October 22, 2020 | 05:00 PM - 07:00 PM
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- Cell-Autonomous Expression of Membrane Transport Proteins in Mammalian Distal Nephron
05:00 PM - 07:00 PM
Martin N. Thomson
Martin N. Thomson
I am a medical student at Charité hospital, Berlin, Germany. Since 2017, I have been involved in basic kidney research in the lab of Prof. Sebastian Bachmann at the Charité Department of Anatomy. My main research interest is the regulation of cation-chloride cotransporters in the distal nephron, especially WNK-SPAK-signaling in the distal convoluted tubule in the context of potassium homeostasis and blood pressure regulation.
Cell-Autonomous Expression of Membrane Transport Proteins in Mammalian Distal Nephron
October 22, 2020 | 05:00 PM - 07:00 PM
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- Optical Clearing and 3D Imaging Reveal a Sexual Dimorphism in the Structure and Remodeling Response of the Distal Convoluted Tubule
05:00 PM - 07:00 PM
Seyedmohammadebrahim Tahaei, PhD
Seyedmohammadebrahim Tahaei, PhD
Dr. Ebrahim Tahaei received his Ph.D. from the Department of Pharmacology, Vanderbilt University in 2018. Currently, he is a postdoctoral fellow in Dr. Paul Welling's laboratory at the Department of Medicine, Johns Hopkins University. In 2019, he received the Ben J. Lipps Postdoctoral Research Fellowship for his proposal on studying the role of Oxgr1, a G-protein coupled receptor, in the mechanisms of diuretics resistance development, and remodeling of the distal nephron. Additionally, he is studying the sexual dimorphism in the structure and function of the distal nephron and its underlying mechanisms.
Optical Clearing and 3D Imaging Reveal a Sexual Dimorphism in the Structure and Remodeling Response of the Distal Convoluted Tubule
October 22, 2020 | 05:00 PM - 07:00 PM
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- Positive Allosteric Modulation of the Calcium-Sensing Receptor (CaSR) by Glucose or Fructose Induces Activation of the Sodium-Chloride Cotransporter (NCC)
05:00 PM - 07:00 PM
Jessica Paola Bahena-López, MD
Jessica Paola Bahena-López, MD
I am a third year PhD student from a MD/PhD program at the National Autonomous University of Mexico. I am very motivated to pursue an academic career focused in translational research in Nephrology aiming to apply findings from basic science to bedside care. Currently I am working to investigate the role of glucose and fructose in the regulation of NCC activity via the CaSR as my PhD project under the guidance of Dr. Gerardo Gamba at the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán in Mexico City
Positive Allosteric Modulation of the Calcium-Sensing Receptor (CaSR) by Glucose or Fructose Induces Activation of the Sodium-Chloride Cotransporter (NCC)
October 22, 2020 | 05:00 PM - 07:00 PM
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- Cross-Talk Between Epithelial Sodium Channel and Basolateral K<sub>ir</sub>4.1/K<sub>ir</sub>5.1 Channels in the Cortical Collecting Duct
05:00 PM - 07:00 PM
Oleg Palygin, PhD
Oleg Palygin, PhD
My research is focused on ion channels and ion transport in the kidney, and I apply multiple sophisticated approaches to address unresolved questions of physiological mechanisms responsible for the regulation of renal function in health and disease. Today, a greater understanding has been achieved of the cellular and molecular mechanisms underlying renal function processes and how these processes may become disordered in chronic kidney disease states such as hypertension, polycystic kidney, and diabetes mellitus. My laboratory is interested in several aspects of the kidney: its ability to control and regulate body electrolytes, its vulnerability to genetically related mutations, oxidative stress, albuminuria, and the role that transport potassium channels, protease-activated receptors, and the purines like ATP play in these processes.
Cross-Talk Between Epithelial Sodium Channel and Basolateral Kir4.1/Kir5.1 Channels in the Cortical Collecting Duct
October 22, 2020 | 05:00 PM - 07:00 PM
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- ClC-K2 Chloride Channel Determines Acid-Base Transport and Chloride Reabsorption in Intercalated Cells of the Collecting Duct
05:00 PM - 07:00 PM
Naghmeh Hassanzadeh Khayyat, PhD
Naghmeh Hassanzadeh Khayyat, PhD
Current position: Postdoctoral Research Fellow at McGovern Medical school, UTHSC at Houston, Texas
Ph.D. in Cell and Molecular Biology (2019), University of Houston, Houston, Texas
M.S. in Cell Biology (2013), Illinois Institute of Technology, Chicago, Illinois
B.S. in Cell and Molecular Biology (2011), University of Tehran, Tehran, Iran
ClC-K2 Chloride Channel Determines Acid-Base Transport and Chloride Reabsorption in Intercalated Cells of the Collecting Duct
October 22, 2020 | 05:00 PM - 07:00 PM
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- Evolutionary Conserved TLDc Domain Defines a New Class of V-ATPase Interacting Proteins
05:00 PM - 07:00 PM
Amity F. Eaton, PhD
Amity F. Eaton, PhD
Amity Eaton is currently a post-doctoral research fellow in the laboratory of Dr. Dennis Brown in the Program for Membrane Biology in the Nephrology Division at the Massachusetts General Hospital in Boston, MA. Her current project investigates the mechanisms of V-ATPase-dependent acid-base balance in kidney intercalated cells. In particular, she is interrogating the function of a newly discovered class of V-ATPase interacting proteins, the TLDc proteins, using animal models in addition to advanced microscopy and biochemical techniques.
Amity received her PhD in cellular biology and molecular physiology from the University of Pittsburgh in 2019 under the mentorship of Dr. Gerard Apodaca. There she studied the mechanotransduction pathways that govern the bladder’s response to forces experienced during filling and voiding. Prior to her dissertation work, Amity received her B.A. in Political Science with a focus on classical political theory from Emory University. She subsequently discovered her love for biomedical research during her two years of work as a research specialist at Emory examining the regulation of Epithelial Na+ Channel (ENaC) activity by PKC in the kidney and the lung.
When she isn’t in the lab, Amity enjoys playing tennis and doing yoga, growing veggies in the Malden community garden, cheering on the Pittsburgh Penguins with a craft beer in hand, and curling up on the sofa with a good (non-scientific) book and her two cats.
Evolutionary Conserved TLDc Domain Defines a New Class of V-ATPase Interacting Proteins
October 22, 2020 | 05:00 PM - 07:00 PM
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- Lysine Acetylation of Aquaporin 3 Affects Water Permeability of the Collecting Duct
05:00 PM - 07:00 PM
Kelly A. Hyndman, PhD
Kelly A. Hyndman, PhD
I am an Assistant Professor of Medicine in the Section of Cardio-Renal Physiology and Medicine, Division of Nephrology at The University of Alabama at Birmingham. My lab currently has two focused areas of research: 1) Understanding the physiology and regulatory mechanisms of lysine acetylation in the kidney, and how enzymes in these pathways are critical for maintain fluid-electrolyte balance and long term blood pressure control. 2) Understanding the pathophysiology of epigenetic regulating pathways in acute kidney injury and chronic kidney disease progression. The overarching theme of my research program is to define the mechanisms of acetyltransferases, deacetylases, and ultimately lysine acetylation in both physiological and pathological states.
Lysine Acetylation of Aquaporin 3 Affects Water Permeability of the Collecting Duct
October 22, 2020 | 05:00 PM - 07:00 PM
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- Role of TRPC3 in the Control of Osmosensitivity and Renal Water Handling in the Mouse Collecting Duct
05:00 PM - 07:00 PM
Victor N. Tomilin, PhD
Victor N. Tomilin, PhD
Current position: Instructor at McGovern Medical school, UTHSC at Houston, Texas
Postdoc: McGovern Medical school, UTHSC at Houston, Texas
Ph.D. in biology/biophysics, Institute of Cytology, Russian Academy of Sciences, Saint-Petersburg, Russia
M.S. in Biophysics, State Polytechnical University of Saint- Petersburg, Russia, The Faculty of Physics and Mechanics, Biophysical Department, cum laude.
Role of TRPC3 in the Control of Osmosensitivity and Renal Water Handling in the Mouse Collecting Duct
October 22, 2020 | 05:00 PM - 07:00 PM
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- Distinct Cellular Osmoregulatory Response in the Skin of Patients with Disturbed Glycosaminoglycan Biosynthesis
05:00 PM - 07:00 PM
Jetta J. Oppelaar, MD
Distinct Cellular Osmoregulatory Response in the Skin of Patients with Disturbed Glycosaminoglycan Biosynthesis
October 22, 2020 | 05:00 PM - 07:00 PM
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