Targeting Complement in ANCA-Associated Vasculitis
October 24, 2020 | 01:00 PM - 02:00 PM
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Educational Symposium
Targeting Complement in ANCA-Associated Vasculitis
October 24, 2020 | 01:00 PM - 02:00 PM
Location: Simulive
Session Description
ANCA-associated vasculitis is a group of life-threatening relapsing diseases. Patients are currently treated with steroids, immunosuppressive drugs, and anti-CD20 antibodies. These treatments improve outcomes but make their own contributions to patient mortality and morbidity. Additional therapeutic strategies based on disease mechanism are needed.
The interaction of ANCA with neutrophils and monocytes is central to the disease pathogenesis. ANCA-stimulated neutrophils contribute to the activation of the alternative complement pathway that acts as an important disease mediator. Moreover, murine disease models have suggested complement as a treatment target in ANCA vasculitis.
Clinical studies that explore inhibiting the C5a-C5a receptor interaction are ongoing, and this symposium reviews both clinical and experimental data on complement in ANCA-associated vasculitis.
Support is provided by an educational grant from ChemoCentryx, Inc.
Learning Objective(s)
- Describe the complement-related pathophysiology in ANCA-associated vasculitis
- Discuss the therapeutic approaches to target the complement system in ANCA-associated vasculitis
Learning Pathway(s)
- Glomerular Diseases
- Pathology
Moderator
- A. Richard Kitching, MBChB, PhD, FASN
Presentations
- Introduction
01:00 PM - 01:10 PM
A. Richard Kitching, MBChB, PhD, FASN
A. Richard Kitching, MBChB, PhD, FASN
Richard Kitching is an academic practicing nephrologist and scientist from Melbourne, Australia. His research focuses on autoimmune kidney disease, from loss of tolerance to effector responses, with a view to using more targeted therapies for these diseases. He holds Monash University and Monash Heath appointments. He heads the Monash Health Vasculitis Clinic, is Chair of the Australian and New Zealand Vasculitis Society (ANZVASC) and is Co-Chair of the ANZ Society of Nephrology Research Advisory Committee. His publications include papers in J Am Soc Nephrol, Kidney International, Clin J Am Soc Nephrol, Nature, Nature Medicine, Nature Reviews Disease Primers, Nature Reviews Nephrology, PNAS, J Clin Invest, J Exp Med and Nature Communications.
Introduction
October 24, 2020 | 01:00 PM - 01:10 PM
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- Complement as a Disease Mechanism in ANCA-Associated Vasculitis
01:10 PM - 01:35 PM
Ralph Kettritz, MD, FASN
Ralph Kettritz, MD, FASN
RALPH KETTRITZ is a graduate in medicine of Leipzig University (1984). After residency in Internal Medicine at the Department for Nephrology and Hypertension in Charite Campus Buch (with Professor Rudolph Natusch and Professor Friedrich C. Luft) he spent postdoctoral years from 1994-1996 at the University at North Carolina at Chapel Hill (with Ronald Falk and Charles Jennette). After returning to Berlin he established a vasculitis research laboratory at the Franz-Volhard Clinic (Charite, Campus-Buch) and completed his training in nephrology. He finished his habilitation in 2000 and became board certified in nephrology in 2002. In 2004 he was appointed a C3 professor for nephrology and hypertension at the Charite. Since 2010 he is a Professor for Internal Medicine and Nephrology and Head of the Vasculitis and Inflammation Program at the Experimental and Clinical Research Center, Charitè-Universitaetsmedizin and Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association.
Certifications:
Board certified in Internal Medicine
Board certified in Nephrology
Complement as a Disease Mechanism in ANCA-Associated Vasculitis
October 24, 2020 | 01:10 PM - 01:35 PM
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- Targeting Complement in Patients with ANCA-Associated Vasculitis
01:35 PM - 02:00 PM
Duvuru Geetha, MD, FASN
Duvuru Geetha, MD, FASN
Dr. Geetha is an associate professor of medicine in the division of nephrology at Johns Hopkins University in Baltimore.Dr.Geetha is the associate director for the Johns Hopkins Vasculitis Center and does clinical and translational research in vasculitis, with a focus on ANCA associated vasculitis and renal disease.
Targeting Complement in Patients with ANCA-Associated Vasculitis
October 24, 2020 | 01:35 PM - 02:00 PM
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