Kidney Week

Educational Symposium

Targeting Complement in ANCA-Associated Vasculitis

October 24, 2020 | 01:00 PM - 02:00 PM

Location: Simulive

Session Description

ANCA-associated vasculitis is a group of life-threatening relapsing diseases. Patients are currently treated with steroids, immunosuppressive drugs, and anti-CD20 antibodies. These treatments improve outcomes but make their own contributions to patient mortality and morbidity. Additional therapeutic strategies based on disease mechanism are needed.

The interaction of ANCA with neutrophils and monocytes is central to the disease pathogenesis. ANCA-stimulated neutrophils contribute to the activation of the alternative complement pathway that acts as an important disease mediator. Moreover, murine disease models have suggested complement as a treatment target in ANCA vasculitis.

Clinical studies that explore inhibiting the C5a-C5a receptor interaction are ongoing, and this symposium reviews both clinical and experimental data on complement in ANCA-associated vasculitis.

Support is provided by an educational grant from ChemoCentryx, Inc.

Learning Objective(s)

• Describe the complement-related pathophysiology in ANCA-associated vasculitis
• Discuss the therapeutic approaches to target the complement system in ANCA-associated vasculitis

Learning Pathway(s)

• Glomerular Diseases
• Pathology

Moderator

• A. Richard Kitching, MBChB, PhD, FASN

Presentations

• Introduction
  01:00 PM - 01:10 PM
  A. Richard Kitching, MBChB, PhD, FASN 
  
  

  A. Richard Kitching, MBChB, PhD, FASN

  Richard Kitching is an academic practicing nephrologist and scientist from Melbourne, Australia. His research focuses on autoimmune kidney disease, from loss of tolerance to effector responses, with a view to using more targeted therapies for these diseases. He holds Monash University and Monash Heath appointments. He heads the Monash Health Vasculitis Clinic, is Chair of the Australian and New Zealand Vasculitis Society (ANZVASC) and is Co-Chair of the ANZ Society of Nephrology Research Advisory Committee. His publications include papers in J Am Soc Nephrol, Kidney International, Clin J Am Soc Nephrol, Nature, Nature Medicine, Nature Reviews Disease Primers, Nature Reviews Nephrology, PNAS, J Clin Invest, J Exp Med and Nature Communications.

Introduction

October 24, 2020 | 01:00 PM - 01:10 PM

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• Complement as a Disease Mechanism in ANCA-Associated Vasculitis
  01:10 PM - 01:35 PM
  Ralph Kettritz, MD, FASN
  

  Ralph Kettritz, MD, FASN

Complement as a Disease Mechanism in ANCA-Associated Vasculitis

October 24, 2020 | 01:10 PM - 01:35 PM

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• Targeting Complement in Patients with ANCA-Associated Vasculitis
  01:35 PM - 02:00 PM
  Duvuru Geetha, MD, FASN
  

  Duvuru Geetha, MD, FASN

Targeting Complement in Patients with ANCA-Associated Vasculitis

October 24, 2020 | 01:35 PM - 02:00 PM

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