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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Educational Symposium

Targeting Complement in ANCA-Associated Vasculitis

October 24, 2020 | 01:00 PM - 02:00 PM

Location: Simulive

Session Description

ANCA-associated vasculitis is a group of life-threatening relapsing diseases. Patients are currently treated with steroids, immunosuppressive drugs, and anti-CD20 antibodies. These treatments improve outcomes but make their own contributions to patient mortality and morbidity. Additional therapeutic strategies based on disease mechanism are needed.

The interaction of ANCA with neutrophils and monocytes is central to the disease pathogenesis. ANCA-stimulated neutrophils contribute to the activation of the alternative complement pathway that acts as an important disease mediator. Moreover, murine disease models have suggested complement as a treatment target in ANCA vasculitis.

Clinical studies that explore inhibiting the C5a-C5a receptor interaction are ongoing, and this symposium reviews both clinical and experimental data on complement in ANCA-associated vasculitis.

Support is provided by an educational grant from ChemoCentryx, Inc.

Learning Objective(s)

  • Describe the complement-related pathophysiology in ANCA-associated vasculitis
  • Discuss the therapeutic approaches to target the complement system in ANCA-associated vasculitis

Learning Pathway(s)

  • Glomerular Diseases
  • Pathology


  • A. Richard Kitching, MBChB, PhD, FASN


  • Introduction
    01:00 PM - 01:10 PM
    A. Richard Kitching, MBChB, PhD, FASN 
  • Complement as a Disease Mechanism in ANCA-Associated Vasculitis
    01:10 PM - 01:35 PM
    Ralph Kettritz, MD, FASN 
  • Targeting Complement in Patients with ANCA-Associated Vasculitis
    01:35 PM - 02:00 PM
    Duvuru Geetha, MD, FASN