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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Cell Death and Clearance in AKI

November 07, 2021 | 10:00 AM - 12:00 PM

Location: Live-Stream, Virtual Only

Session Description

Tubular apoptosis has been shown in preclinical models and some clinical samples from patients with AKI. Mechanistically, apoptotic cell death may result from well-described extrinsic and intrinsic pathways and endoplasmic reticulum stress. Additionally, other cell death pathways, such as pyroptosis and ferroptosis, may also have pathophysiologic relevance in AKI. It has been demonstrated that removal of dying cells plays a critical role in the resolution of AKI. This session discusses mechanisms and outcomes of cell death and clearance in AKI.

Learning Objective(s)

  • Describe the mechanisms and outcomes of cell death in the kidneys
  • Describe the role of phagocytosis of dead cells in AKI
  • Discuss immune regulation in the kidneys

Learning Pathway(s)

  • Acute Kidney Injury
  • Chronic Kidney Disease

Moderators

  • Lakshman Gunaratnam, MD
  • Reena Rao, PhD

Presentations

  • Mechanisms of Cell Death in AKI
    10:00 AM - 10:30 AM
    Hülya Bayir, MD
  • Autophagy in AKI
    10:30 AM - 11:00 AM
    Zheng Dong, PhD, FASN
  • C-Type Lectin (Mincle) Mediates Cell Death-Triggered Inflammation in AKI
    11:00 AM - 11:30 AM
    Takayoshi Suganami, MD, PhD
  • Boosting Efferocytosis in AKI
    11:30 AM - 12:00 PM
    Sho Morioka, PhD