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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Update on Renal Amyloidosis and Fibrillary Glomerulonephritis

November 06, 2021 | 02:00 PM - 04:00 PM

Location: Live-Stream, Virtual Only

Session Description

The last decade has witnessed the discovery of new forms of amyloidosis that involve the kidney and of the molecular composition of the glomerular deposits in fibrillary glomerulonephritis. In addition, there is greater knowledge about the pathogenesis of amyloid fibril formation and the molecular properties that render certain immunoglobulin light chains amyloidogenic. This session discusses how this increased knowledge offers new opportunities for therapeutically preventing, interrupting, and reversing amyloid deposition in the kidney and other organs.

Learning Objective(s)

  • Examine the recently described forms of amyloidosis that involve the kidney and their clinical and pathologic features
  • Summarize the process of fibril generation in amyloid light-chain amyloidosis, and identify potential therapeutic strategies for interrupting it
  • Describe the importance of DNAJB9 in fibrillary glomerulonephritis, and examine its potential involvement in the pathogenesis of this lesion

Learning Pathway(s)

  • Pathology
  • Glomerular Diseases


  • Nattawat Klomjit, MD
  • Maria M. Picken, MD, PhD, FASN