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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Challenge of Kidney Diseases in Patients with Monoclonal Gammopathy

November 05, 2021 | 10:30 AM - 12:30 PM

Location: Live-Stream, Virtual Only

Session Description

Monoclonal gammopathies cause kidney injury with a wide spectrum of histologic findings. Properties that make a monoclonal protein pathogenic and the molecular mechanisms contributing to the various renal manifestations are under research. Clinicians are particularly challenged when the patient's monoclonal gammopathy lacks the definition of a malignant disease or when the protein is not detected in the kidney tissue. This session discusses the challenges in selecting the right treatment strategy, although selecting the option that effectively deletes the inflicting B cell or plasma cell clone remains a difficult issue.

Learning Objective(s)

  • Describe the various histologic manifestations of monoclonal gammopathies within the kidneys
  • Describe the molecular mechanism leading to kidney injury
  • State the appropriate tests to establish a diagnosis and search for the inflicting cell clone
  • Outline the appropriate treatment protocol for targeting the aberrant B cell or plasma cell clone

Learning Pathway(s)

  • Glomerular Diseases
  • Acute Kidney Injury


  • Cynthia C. Nast, MD, FASN
  • Jack F. Wetzels, MD, PhD


  • Spectrum of Kidney Lesions in Monoclonal Gammopathies
    10:30 AM - 11:00 AM
    Vanesa Bijol, MD
  • Diagnostic Workup When Monoclonal Gammopathy-Related Kidney Disease Is Suspected
    11:00 AM - 11:30 AM
    Frank Bridoux, MD, PhD
  • How Monoclonal Immunoglobulins Cause Kidney Injury
    11:30 AM - 12:00 PM
    Christophe Sirac, PhD
  • Targeting the (Right) Pathogenic B Cell and Plasma Cell Clone
    12:00 PM - 12:30 PM
    Nelson Leung, MD