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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Translational Session

Role of the Calcium-Sensing Receptor in Non-Parathyroid Tissues

November 04, 2021 | 10:00 AM - 12:00 PM

Location: On-Demand, Virtual Only

Session Description

The calcium-sensing receptor (CaSR) has a major role in regulating PTH production and serves as a major therapeutic target for controlling secondary hyperparathyroidism in ESKD. The CaSR receptor is widely expressed in other tissues, and evolving evidence suggests a function for this receptor in many important physiologic processes. This session presents current evidence for the role of the CaSR in physiologic processes unrelated to parathyroid function.

Learning Objective(s)

  • Describe tissue distribution and regulation of the CaSR
  • Discuss current understanding of the role of the CaSR in immune cell function
  • Describe the major functions of the CaSR in regulating mineral homeostasis and water excretion by the kidney
  • Summarize how the CaSR regulates intestinal epithelial cell biology and intestinal function

Learning Pathway(s)

  • Bone and Mineral Metabolism
  • Cell and Transport Physiology


  • Leonidas Tsiokas, PhD
  • Katherine Wesseling-Perry, MD, MS


  • Overview of the Expression Patterns, Regulation, and Function of CaSR
    10:00 AM - 12:00 PM
    Wenhan Chang, PhD
  • CaSR and Immune Cell Function
    10:00 AM - 12:00 PM
    Justine Bacchetta, MD, PhD
  • CaSR in the Kidneys
    10:00 AM - 12:00 PM
    Marianna Ranieri, PhD
  • CaSR in the Gut
    10:00 AM - 12:00 PM
    Sam Cheng, MD, PhD