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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Shedding Light on Cell Surface Proteins Uromodulin and Mucin 1

November 06, 2021 | 10:00 AM - 12:00 PM

Location: On-Demand, Virtual Only

Session Description

Uromodulin and mucin 1 are cell surface proteins that are membrane-anchored and expressed in specific tubular segments. In this session, expert speakers shed new light on their physiological and pathophysiological relevance in the kidney. Discussion includes how these proteins regulate the renal transport of salt, calcium, and magnesium. The contribution of uromodulin and mucin 1 in an experimental model of AKI is discussed, as well as the deleterious consequences of mutations in these genes as a cause of CKD and potential targeted therapies.

Learning Objective(s)

  • Describe the structure of uromodulin and how it can affect urinary tract infection as well as renal salt sensitivity
  • Define how uromodulin and mucin 1 regulate renal handling of calcium and magnesium
  • Discuss the relevance of uromodulin and mucin 1 in AKI
  • Explain the link between mutations in UMOD and MUC1 and autosomal dominant tubulointerstitial kidney disease

Learning Pathway(s)

  • Cell and Transport Physiology
  • Genetic Diseases of the Kidneys


  • Sarah Cormican, MBChB
  • Carolyn M. Ecelbarger, PhD