Basic/Clinical Science Session
Maladaptive Responses in AKI
November 04, 2021 | 10:00 AM - 12:00 PM
Location: On-Demand, Virtual Only
Session Description
Recently, there has been an increased appreciation of the long-term sequelae of AKI and the potential development of CKD. The complex interplay between endothelial cells, immune cells, pericytes, and fibroblasts often converge in the tubular epithelial cells that play a central role. This session discusses the molecular and cellular mechanisms involved in maladaptive tissue responses following AKI.
Learning Objective(s)
- Discuss novel transcriptional signatures revealed by single-cell transcriptional profiling of AKI and assess their potential implications in the AKI-to-CKD transition
- Discuss the role of hypermethylation in maintaining a profibrotic pericyte phenotype
- Examine the role of oxidative stress in AKI-to-CKD transition
- Describe how tissue repair signaling pathways after AKI may drive neoplastic growth
Learning Pathway(s)
- Acute Kidney Injury
- Chronic Kidney Disease
Moderators
Presentations
- Single-Cell Transcriptional Profiling of AKI
10:00 AM - 12:00 PM
- Methylation in Pericytes After Acute Injury Promotes CKD
10:00 AM - 12:00 PM
- Oxidative Stress in AKI-to-CKD Transition
10:00 AM - 12:00 PM
- AKI-Induced Carcinogenesis
10:00 AM - 12:00 PM