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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Maladaptive Responses in AKI

November 04, 2021 | 10:00 AM - 12:00 PM

Location: On-Demand, Virtual Only

Session Description

Recently, there has been an increased appreciation of the long-term sequelae of AKI and the potential development of CKD. The complex interplay between endothelial cells, immune cells, pericytes, and fibroblasts often converge in the tubular epithelial cells that play a central role. This session discusses the molecular and cellular mechanisms involved in maladaptive tissue responses following AKI.

Learning Objective(s)

  • Discuss novel transcriptional signatures revealed by single-cell transcriptional profiling of AKI and assess their potential implications in the AKI-to-CKD transition
  • Discuss the role of hypermethylation in maintaining a profibrotic pericyte phenotype
  • Examine the contribution of the store-operated calcium channel ORAI1 in sustaining Th17-driven inflammatory response in the AKI-to-CKD transition
  • Describe how tissue repair signaling pathways after AKI may drive neoplastic growth

Learning Pathway(s)

  • Acute Kidney Injury
  • Chronic Kidney Disease


  • Sunder Sims-Lucas, PhD
  • Motoko Yanagita, MD, PhD


  • Single-Cell Transcriptional Profiling of AKI
    10:00 AM - 12:00 PM
    Benjamin D. Humphreys, MD, PhD, FASN
  • Methylation in Pericytes After Acute Injury Promotes CKD
    10:00 AM - 12:00 PM
    Shuei-Liong Lin, MD, PhD
  • Oxidative Stress in AKI-to-CKD Transition
    10:00 AM - 12:00 PM
    Tomokazu Souma, MD, PhD
  • AKI-Induced Carcinogenesis
    10:00 AM - 12:00 PM
    Paola Romagnani, MD, PhD