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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Small Giants in the Cell: Organelles in the Kidney World

November 05, 2021 | 10:00 AM - 12:00 PM

Location: On-Demand, Virtual Only

Session Description

Kidney diseases derive from abnormal organelle functions. Mitochondrial damage induces energy depletion and oxidative stress, playing a crucial role in the pathogenesis of glomerular and tubular damages. Lysosome is a membrane-bound cell organelle containing digestive enzymes and contributes to cellular metabolism. Primary cilium is another important organelle that is deeply involved in polycystic kidney and other kidney diseases. This session discusses recent evidence that these organelles cross-talk and maintain cell fate.

Learning Objective(s)

  • Describe the updated pathophysiology of mitochondrial dysfunction
  • Define the pathophysiology of lysosomal metabolism
  • Discuss the updated pathophysiology of primary cilia dysfunction
  • Explain the organelle and metabolic consequences of medication used for patients with CKD
  • Describe the pathomechanisms of organelle cross-talk

Learning Pathway(s)

  • Chronic Kidney Disease
  • Cell and Transport Physiology


  • Reiko Inagi, PhD
  • Stefan Somlo, MD


  • Mitochondria: Janus of CKD
    10:00 AM - 12:00 PM
    Ariela Benigni, PhD
  • Lysosome-Autophagy Axis in Kidney Metabolic Damage
    10:00 AM - 12:00 PM
    Yoshitaka Isaka, MD, PhD
  • Sensing and Consequences of Primary Cilia
    10:00 AM - 12:00 PM
    Paul G. DeCaen, PhD
  • Organelle-Related Drug Development
    10:00 AM - 12:00 PM
    Anna Greka, MD, PhD