ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Epigenetic and Epigenome Modifications and Diabetic Kidney Disease

November 04, 2021 | 10:00 AM - 12:00 PM

Location: On-Demand, Virtual Only

Session Description

Epigenetic modifications, including histone modification, DNA methylation, and non-coding RNAs, play important roles in diabetic kidney disease (DKD). This session explores the role of epigenetic factors and noncoding RNAs as biomarkers and drug targets in DKD.

Learning Objective(s)

  • Explain the altered DNA methylation patterns associated with DKD phenotypes
  • Describe the mechanisms whereby epigenetic memory dictates subsequent development of DKD
  • Describe the role of epigenetic modification of stem cell plasticity in DKD
  • Discuss the role of long intergenic noncoding RNAs (lincRNAs) as mediators of vascular complications of diabetes

Learning Pathway(s)

  • Diabetes and Metabolism


  • Eoin Brennan, PhD
  • Donald Fraser, MBChB, PhD


  • Integrated Analysis of Genetic and Epigenetic Variation in Diabetic Kidney Disease
    10:00 AM - 12:00 PM
    Xin Sheng, PhD
  • DNA Methylation and Metabolic Memory
    10:00 AM - 12:00 PM
    Rama Natarajan, PhD, FASN
  • Exploiting Renal Progenitor Cells in Diabetic Kidney Disease
    10:00 AM - 12:00 PM
    Paola Romagnani, MD, PhD
  • Long Intergenic Noncoding RNAs in Vascular Complications of Diabetes
    10:00 AM - 12:00 PM
    Muredach Reilly, MBChB, MS