ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Translational Session

Non-GWAS Approaches to Searching for Novel Genes for Diabetic Kidney Disease

November 05, 2021 | 10:00 AM - 12:00 PM

Location: On-Demand, Virtual Only

Session Description

Significant progress has been made in learning about the genetic architecture of diabetic kidney disease (DKD) using genome-wide association studies (GWAS). Multiple genetic loci, mostly of small effects, were identified, but they have limited usefulness. These loci are in intergenic regions, and their function is unknown. This session discusses alternative approaches to use genetic information to learn more about genes and proteins involved in the development of DKD. Such knowledge may help identify new targets for new therapies.

Learning Objective(s)

  • Describe the usefulness of searching for amino-acid changing rare genetic variants in studies on genetics of DKD
  • Summarize different study designs to search for amino-acid changing rare genetic variants associated with DKD
  • Discuss the usefulness of genetic mapping of kidney phenotypes using the mouse diversity outbred population

Learning Pathway(s)

  • Diabetes and Metabolism
  • Genetic Diseases of the Kidneys


  • M. Luiza A. Caramori, MD, MS, PhD
  • Martin R. Pollak, MD