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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Home Improvement: Novel Mechanisms of Nephron Remodeling

November 05, 2021 | 02:00 PM - 04:00 PM

Location: Live-Stream, Virtual Only

Session Description

The nephron is responsible for solute reabsorption and secretion and is divided into distinct cell types in an axial orientation. We often depict the adult nephron as a static structure with specialized and terminally differentiated segments. However, imaging and single-cell techniques have allowed us to better characterize stimuli and mechanisms that lead to hyperplasia, hypertrophy, hypoplasia, and atrophy of different cell types. This session discusses these pathways in the pursuit of better understanding renal physiology and pathophysiology and novel treatment paradigms.

Learning Objective(s)

  • Describe the techniques available to characterize tubular epithelial cell remodeling
  • Outline examples of physiologic and pathophysiologic stimuli that remodel the nephron
  • Discuss the mechanisms that alter cell identity and function and lead to hyperplasia and hypertrophy

Learning Pathway(s)

  • Cell and Transport Physiology
  • Pathology


  • Turgay Saritas, MD
  • Maria Luisa S. Sequeira Lopez, MD