ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Basic/Clinical Science Session

Skeletal Muscle: An Underappreciated Target Organ in CKD

November 03, 2022 | 02:00 PM - 04:00 PM

Location: W304, Orange County Convention Center, West Building

Session Description

CKD is recognized as a systemic disorder in which pathophysiology in multiple target organs contributes to poor patient outcomes. Skeletal muscle is not typically considered among these target organs despite a plethora of research demonstrating skeletal muscle dysfunction in CKD. This session highlights recent work in both humans and animal models that has expanded our understanding of the multiple deleterious effects of CKD and uremia on skeletal muscle function and patient-centered outcomes.

Learning Objective(s)

  • Discuss the importance of intact mitochondrial function for preserving physical function and exercise tolerance and the effect of mitochondrial dysregulation in CKD
  • Describe the contribution of impaired skeletal muscle regenerative mechanisms in CKD to development of muscle fibrosis and functional decline
  • Define the mechanisms by which CKD impairs skeletal muscle proteostasis
  • Explain the importance of muscle-kidney cross-talk in preserving muscle and kidney health

Learning Pathway(s)

  • CKD Non-Dialysis
  • Dialysis

Moderators

  • Clara Bohm, MD, MPH
  • Hui Cai, MD, FASN

Presentations

  • Mitochondrial Health and Muscle Bioenergetics in CKD
    02:00 PM - 02:30 PM
    Baback Roshanravan, MD, MS, MPH, FASN
  • Skeletal Muscle Regeneration and Fibrosis in CKD and Dialysis
    02:30 PM - 03:00 PM
    Matthew K. Abramowitz, MD, MS, FASN
  • Muscle Wasting, Autophagy, and CKD
    03:00 PM - 03:30 PM
    Xiaonan H. Wang, MD
  • Insights into Muscle-Kidney Cross-Talk
    03:30 PM - 04:00 PM
    Tobias B. Huber, MD, FASN