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To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Basic/Clinical Science Session

Genetics and Clinical Implications of APOL1 Nephropathy

November 05, 2022 | 02:00 PM - 04:00 PM

Location: WF1 Tangerine, Orange County Convention Center‚ West Building

Session Description

A significant factor in the disparity of CKD burden in Black patients compared with those of other racial and ethnic groups is attributed to genetic variants in APOL1. This session explores the genetics, biology, and clinical considerations of APOL1 nephropathy. Particular emphasis is given to APOL1 population genetics, mechanistic models, and clinical applications, including kidney transplant considerations.

Learning Objective(s)

  • Provide a comprehensive overview of APOL1 population genetics and its clinical spectrum
  • Describe APOL1 models and current understanding of biologic mechanisms
  • Discuss considerations for kidney transplantation in donors and recipients with high-risk APOL1 alleles
  • Identify potential therapeutic agents in APOL1 nephropathy

Learning Pathway(s)

  • Genetic Diseases and Development


  • Opeyemi A. Olabisi, MD, PhD
  • John R. Sedor, MD, FASN


  • Population Genetics of APOL1 and Its Clinical Spectrum
    02:00 PM - 02:30 PM
    Rulan S. Parekh, MD, MS, FASN
  • APOL1 and Potential Implications for Kidney Transplantation
    02:30 PM - 03:00 PM
    Barry I. Freedman, MD
  • Biology of APOL1 Nephropathy
    03:00 PM - 03:30 PM
    Martin Pollak, MD
  • Therapeutic Development in APOL1 Nephropathy
    03:30 PM - 04:00 PM
    Ogo I. Egbuna, MD, MS, MSc, FASN