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To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Clinical Practice Session

Antigens Underlying Glomerular Diseases: Diagnostic, Pathogenic, and Clinical Implications

November 05, 2022 | 02:00 PM - 04:00 PM

Location: W314, Orange County Convention Center‚ West Building

Session Description

Until recently, the pathology of glomerular diseases has been characterized primarily by morphology, including histology, electron microscopy, and immunohistology. However, morphology-based characterization provides limited insight into pathogenesis, disease variants with similar morphology, and potential for development of specific therapeutic approaches. This session describes progressive advances over the past decade in identifying the roles of specific antigens in the pathogenesis of different types of glomerular diseases, including membranous nephropathy.

Support is provided by an educational grant from Travere Therapeutics, Inc.

Learning Objective(s)

  • Identify the antigens involved in the pathogenesis of membranous nephropathy; the major clinical, demographic, and prognostic associations with each antigen; and potential therapeutic targets
  • Describe the roles of ANCA antigens and complement in the pathogenesis of ANCA glomerulonephritis (GN) and vasculitis and potential new therapeutic approaches based on new pathogenic insights
  • Explain how specific bacterial and viral antigens promote various forms of GN and how this contributes to their pathology, immunopathology, and clinical manifestations

Learning Pathway(s)

  • Pathology
  • Glomerular Diseases


  • Tiffany Caza, MD, PhD
  • Shikha Wadhwani, MD, MS