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To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Translational Session

Molecular Diagnostics in Interpretation of Native and Transplant Kidney Biopsies

November 04, 2022 | 02:00 PM - 04:00 PM

Location: W315, Orange County Convention Center‚ West Building

Session Description

Morphology-based interpretation of both native and transplant kidney biopsies has important limitations, including variability between pathologists and limited insight into pathogenesis. This session describes the application of molecular diagnostics to the analysis of tissue from kidney biopsies, which has the potential to improve on diagnostic accuracy, better identify simultaneous disease processes, identify different injury pathways that lead to similar morphologic lesions, help guide therapy, and develop classifications of kidney diseases based on pathogenesis rather than morphology alone.

Support is provided by an educational grant from Travere Therapeutics, Inc.

Learning Objective(s)

  • Describe how the use of molecular diagnostics is allowing the classification of podocytopathies based on pathogenesis rather than morphology
  • Explain how transcriptomic analysis can improve understanding of the pathogenesis of glomerular diseases and identify potential targets for treatment
  • Discuss the most recent developments in the molecular analysis of kidney transplant biopsies and situations where molecular analysis is most useful for kidney transplant biopsy interpretation

Learning Pathway(s)

  • Pathology
  • Glomerular Diseases


  • Enver Akalin, MD, FASN
  • Ivy A. Rosales, MD


  • Glomerular Transcriptomic Profiles in Nephrotic Syndrome
    02:00 PM - 02:30 PM
    Jeffrey B. Hodgin, MD, PhD
  • Transcriptomic Studies in IgA Nephropathy and Lupus Nephritis
    02:30 PM - 03:00 PM
    Francesco Paolo Schena, MD, FASN
  • Transcriptomics and the Pathogenesis of Diabetic Nephropathy
    03:00 PM - 03:30 PM
    Raymond C. Harris, MD, FASN
  • Molecular Diagnostics of Kidney Transplant Rejection: An Update
    03:30 PM - 04:00 PM
    Candice A. Roufosse, MD, PhD