Kidney Week

Translational Session

Dietary and Metabolic Interventions in ADPKD: The Rationale and Clinical Benefit

November 03, 2023 | 04:30 PM - 06:00 PM

Location: Room 114 (Nutter Theatre), Pennsylvania Convention Center

Session Description

ADPKD cells exhibit metabolic abnormalities including increased aerobic glycolysis (Warburg effect). Recent pilot studies, along with preclinical experiments, demonstrate that dietary interventions and interventions to address metabolic abnormalities may be able to slow ADPKD progression. This session provides an overview on metabolic abnormalities seen in ADPKD and the biological justification for targeting these changes to modify disease. Talks include discussion of recent mechanistic and clinical trial data that support these new approaches.

Learning Objective(s)

• Explain how abnormal cellular biology of ADPKD epithelium results in enhanced aerobic glycolysis
• Characterize the effect of dietary protein on ADPKD physiology and progression
• Discuss ADPKD research on ketogenic diets
• Describe the therapeutic role for targeting adiposity and caloric restriction in ADPKD

Learning Pathway(s)

• Genetic Diseases and Development
• CKD Non-Dialysis

Moderators

• Meyeon Park, MD, FASN
• Ronald D. Perrone, MD, FASN

Presentations

• Biological Basis for Metabolic Treatment of ADPKD: Increased Aerobic Glycolysis (Warburg Effect)
  04:30 PM - 04:50 PM
  
  • Maria V. Irazabal, MD, PhD
  Maria V. Irazabal, MD, PhD

Biological Basis for Metabolic Treatment of ADPKD: Increased Aerobic Glycolysis (Warburg Effect)

November 03, 2023 | 04:30 PM - 04:50 PM

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• Dietary Protein, Immune Cells, and ADPKD Progression
  04:50 PM - 05:10 PM
  
  • Takamitsu Saigusa, MD
  Takamitsu Saigusa, MD

Dietary Protein, Immune Cells, and ADPKD Progression

November 03, 2023 | 04:50 PM - 05:10 PM

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• Ketogenic Diet and ADPKD
  05:10 PM - 05:30 PM
  
  • Roman-Ulrich Mueller, MD
  Roman-Ulrich Mueller, MD

Ketogenic Diet and ADPKD

November 03, 2023 | 05:10 PM - 05:30 PM

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• Targeting Adiposity and Caloric Restriction in ADPKD
  05:30 PM - 05:50 PM
  
  • Kristen L. Nowak, PhD, MPH
  Kristen L. Nowak, PhD, MPH

Targeting Adiposity and Caloric Restriction in ADPKD

November 03, 2023 | 05:30 PM - 05:50 PM

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• Q&A
  05:50 PM - 06:00 PM
  

Q&A

November 03, 2023 | 05:50 PM - 06:00 PM

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