ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Basic/Clinical Science Session

APOL1 and Kidney Transplantation

November 02, 2023 | 10:30 AM - 12:30 PM

Location: Room 115, Pennsylvania Convention Center

Session Description

The spectrum of APOL1-associated nephropathy includes more rapid failure of transplanted kidneys from donors with APOL1 high-risk genotypes. Living kidney donors with APOL1 high-risk genotypes are also at heightened risk for CKD. This session reviews existing data on APOL1 in kidney transplantation and provide an update on progress in the National Institutes of Health (NIH) APOLLO Consortium. Beyond the effects of donor genotypes, recent data implicating transplant recipient APOL1 genotypes on the immune response, transplant rejection, and graft survival will be discussed.

Learning Objective(s)

  • Explain the role of APOL1 high-risk genotypes on kidney transplant outcomes with update from the NIH-sponsored APOLLO study
  • Describe the impact of APOL1 screening in the evaluation and selection of living kidney donors
  • Outline potential benefits and risks of genotyping live donor candidates
  • Discuss possible impact of recipient APOL1 genotypes on the transplant rejection and graft survival

Learning Pathway(s)

  • Kidney Transplantation